649757-47-1Relevant articles and documents
Synthesis and combinatorial approach of the reactivity of 6- and 7-arylthieno[3,2-d][1,3]oxazine-2,4-diones
Le Foulon, Fran?ois-Xavier,Braud, Emmanuelle,Fabis, Frédéric,Lancelot, Jean-Charles,Rault, Sylvain
, p. 10051 - 10057 (2007/10/03)
This paper describes a general procedure for the synthesis of new substituted thiaisatoic anhydrides or 6- or 7-aryl-1H-thiéno[3,2-d][1,3] oxazine-2,4-diones 3a-j and 4a-f. They were synthesized in large scale under microwave heating conditions with high yields. The reactivity vs nucleophilic reagents of these compounds was studied and permitted to develop a simple combinatorial procedure to synthesize a library of new thiophene ureidoacids 7a-j and 8a-j.