65018-89-5 Usage
Description
6-Cyano-trans-3-bromo-3,4-dihydro-2,2-dimethyl-2H-benzo-[b]-pyran-4-ol, with the chemical abstracts service number 65018-89-5, is a synthetic organic compound characterized by its unique molecular structure. It features a benzo[b]pyran core with a cyano group, a bromo substituent, and two methyl groups, which contribute to its chemical properties and potential applications in various fields.
Uses
Used in Organic Synthesis:
6-Cyano-trans-3-bromo-3,4-dihydro-2,2-dimethyl-2H-benzo-[b]-pyran-4-ol is utilized as a key intermediate in organic synthesis for the development of new chemical entities. Its unique structure allows for further functionalization and modification, making it a valuable building block for the creation of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 6-Cyano-trans-3-bromo-3,4-dihydro-2,2-dimethyl-2H-benzo-[b]-pyran-4-ol is used as a precursor for the synthesis of novel drug candidates. Its structural features can be exploited to design molecules with specific biological activities, targeting a range of therapeutic areas such as oncology, neurology, and infectious diseases.
Used in Agrochemical Industry:
6-Cyano-trans-3-bromo-3,4-dihydro-2,2-dimethyl-2H-benzo-[b]-pyran-4-ol also finds application in the agrochemical industry, where it serves as a starting material for the synthesis of new pesticides and herbicides. Its chemical properties can be tailored to create compounds with improved efficacy and selectivity, contributing to more sustainable agricultural practices.
Used in Specialty Chemicals:
In the specialty chemicals sector, 6-Cyano-trans-3-bromo-3,4-dihydro-2,2-dimethyl-2H-benzo-[b]-pyran-4-ol is employed as a versatile intermediate for the production of various high-value chemicals. Its adaptability in synthesis allows for the development of innovative materials with applications in coatings, dyes, and other industrial processes.
Check Digit Verification of cas no
The CAS Registry Mumber 65018-89-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,5,0,1 and 8 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 65018-89:
(7*6)+(6*5)+(5*0)+(4*1)+(3*8)+(2*8)+(1*9)=125
125 % 10 = 5
So 65018-89-5 is a valid CAS Registry Number.
65018-89-5Relevant articles and documents
Synthesis and antihypertensive activity of substituted trans-4-amino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-3-ols
Evans, John M.,Fake, Charles S.,Hamilton, Thomas C.,Poyser, Robert H.,Watts, Eric A.
, p. 1582 - 1589 (2007/10/02)
A series of novel substituted trans-4-amino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-3-ols was prepared and tested for antihypertensive activity in the conscious deoxycorticosterone acetate (DOCA)/saline treated hypertensive rat. Optimum blood pressure lowering activity requires 6-substitution by a strong electron-withdrawing group, together with a pyrrolidino or piperidino group at the 4 position. Exceptions to this were the 7-nitro-4-pyrrolidine analogue and the 6-nitro-3-chloropropylamine, which retained marked antihypertensive activity. All of these compounds were direct vasodilators and had comparable antihypertensive activity to hydralazine and to the calcium antagonist, nifedipine. The synthetic route to these compounds involves cyclization of propargyl ethers to 2H-1-benzopyrans, followed by conversion via bromohydrins to 3,4-epoxides, which were ring opened with the appropriate amines. Meta-substituted propargyl ethers gave both 5- and 7-substituted benzopyrans on thermal cyclization, the former predominating. A new route to 2,2-dimethyl-7-nitrobenzopyran is described.
