65090-78-0

Basic information

• Product Name: 2-Bromo-3-methoxypropionic acid
• Synonyms: 2-Bromo-3-methoxypropionic acid;2-Bromo-3-methoxypropanoic acid;Propanoic acid, 2-broMo-3-Methoxy-
• CAS NO: 65090-78-0
• Molecular Formula: C₄H₇BrO₃
• Molecular Weight: 183
• Mol File: 65090-78-0.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 257 ºC
• Flash Point: 109 ºC
• Appearance: /
• Density: 1.677
• Vapor Pressure: 0.005mmHg at 25°C
• Refractive Index: 1.491
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 2.59±0.10(Predicted)
• CAS DataBase Reference: 2-Bromo-3-methoxypropionic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-3-methoxypropionic acid(65090-78-0)
• EPA Substance Registry System: 2-Bromo-3-methoxypropionic acid(65090-78-0)

Safety Data

• Hazardous Substances Data: 65090-78-0(Hazardous Substances Data)

Usage

General Description

2-Bromo-3-methoxypropionic acid is a chemical compound with the molecular formula C4H7BrO3. It is a white solid that is commonly used in organic synthesis as an intermediate in the production of pharmaceuticals and agrochemicals. The compound is also known for its potential anti-inflammatory and anticancer properties. It is primarily used as a building block in the synthesis of various organic compounds due to its reactivity and ability to undergo various chemical reactions. Additionally, 2-Bromo-3-methoxypropionic acid is also used as a reagent in the preparation of carboxylic acid derivatives and is a valuable compound in the field of medicinal chemistry and drug discovery.

InChI:InChI=1/C4H7BrO3/c1-8-2-3(5)4(6)7/h3H,2H2,1H3,(H,6,7)

Upstream product

• 10443-65-9 2-bromo-2-propenoic acid 
• 124-41-4 sodium methylate 
• 27704-96-7 methyl 2-bromo-3-methoxypropionate 
• 3674-13-3 2,3-dibromopropionic acid ethyl ester 
• 67-56-1 methanol 
• 1729-67-5 Methyl 2,3-dibromopropionate 

Downstream Products

• 126135-45-3 2-(2-isopropenyl-5-methylphenoxy)-3-methoxypropanoic acid 
• 19794-53-7 3-methoxy-2-aminopropionic acid 
• 705283-58-5 N-benzyl-2-bromo-3-methoxypropionamide 

Relevant articles and documents

Tailored Synthesis of Skeletally Diverse Stemona Alkaloids through Chemoselective Dyotropic Rearrangements of β-Lactones

The collective synthesis of skeletally diverse Stemona alkaloids featuring tailored dyotropic rearrangements of β-lactones as key elements is described. Specifically, three typical 5/7/5 tricyclic skeletons associated with stemoamide, tuberostemospiroline and parvistemonine were first accessed through chemoselective dyotropic rearrangements of β-lactones involving alkyl, hydrogen, and aryl migration, respectively. By the rational manipulation of substrate structures and reaction conditions, these dyotropic rearrangements proceeded with excellent efficiency, good chemoselectivity and high stereospecificity. Furthermore, several polycyclic Stemona alkaloids, including saxorumamide, isosaxorumamide, stemonine and bisdehydroneostemoninine, were obtained from the aforementioned tricyclic skeletons through late-stage derivatizations. A novel visible-light photoredox-catalyzed formal [3+2] cycloaddition was also developed, which offers a valuable tool for accessing oxaspirobutenolide and related scaffolds.

N-Substituted amino acid N′-benzylamides: Synthesis, anticonvulsant, and metabolic activities

Amino acid amides (AAA) were prepared and evaluated in seizure models. The AAA displayed moderate-to-excellent activity in the maximal electroshock seizure (MES) test and were devoid of activity in the subcutaneous Metrazol-induced (scMet) seizure test. The AAA anticonvulsant activity was neither strongly influenced by the C(2) substituent nor by the degree of terminal amine substitution. An in vitro metabolism study suggested that the structure-activity relationship pattern was due, in part, to metabolic processes that occurred at the N-terminal amine unit.

N-ALKYNYL-2- (SUBSTITUTED PHENOXY) ALKYLAMIDES AND THEIR USE AS FUNGICIDES

Fungicidal compounds of the general formula (1) wherein X, Y, Z, R1, R2, R3, R4 and R5 have the definitions given in claim 1.