65130-31-6

Basic information

• Product Name: Ethanone, 1-(2-bromo-5-nitrophenyl)-
• Synonyms: 2-BROMO-5-NITROACETOPHENONE;1-(2-Bromo-5-nitro-phenyl)-ethanone;Ethanone, 1-(2-bromo-5-nitrophenyl)-
• CAS NO: 65130-31-6
• Molecular Formula: C₈H₆BrNO₃
• Molecular Weight: 244.04
• Product Categories: Adehydes, Acetals & Ketones;Bromine Compounds;Nitro Compounds
• Mol File: 65130-31-6.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Ethanone, 1-(2-bromo-5-nitrophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-(2-bromo-5-nitrophenyl)-(65130-31-6)
• EPA Substance Registry System: Ethanone, 1-(2-bromo-5-nitrophenyl)-(65130-31-6)

Safety Data

• Hazardous Substances Data: 65130-31-6(Hazardous Substances Data)

Usage

General Description

Ethanone, 1-(2-bromo-5-nitrophenyl)-, also known as bromonitro diphenyl ketone, is a chemical compound with the molecular formula C8H6BrNO3. It is a yellow solid with a melting point of 182-184°C and is primarily used as an intermediate in organic synthesis. Ethanone, 1-(2-bromo-5-nitrophenyl)- is utilized in the production of pharmaceuticals, dyes, and other organic compounds. It is important to handle this chemical with care, as it may cause irritation to the skin, eyes, and respiratory system if not properly handled.

Upstream product

• 2142-69-0 2-bromophenyl methyl ketone 
• 32580-41-9 1-(2-amino-5-nitro-phenyl)ethanone 
• 80887-01-0 2-bromo-5-nitrobenzoyl chloride 
• 551-93-9 2-aminoacetophenone 
• 70-11-1 α-bromoacetophenone 

Downstream Products

• 40621-84-9 3-methyl-5-nitro-1H-indazole 
• 54595-48-1 (Z)-1-(2-bromo-5-nitrophenyl)ethanone oxime 
• 54582-26-2 α-6-bromo-3-nitro-acetophenone oxime 
• 56759-35-4 2-bromo-1-(2-bromo-5-nitro-phenyl)-ethanone 
• 108849-67-8 1-[2-(2-amino-phenylsulfanyl)-5-nitro-phenyl]-ethanone 
• 229156-26-7 (S)-1-(2-Bromo-5-nitro-phenyl)-ethanol 
• 229156-24-5 1-[(R)-1-(2-Bromo-5-nitro-phenyl)-ethyl]-pyrrolidine 
• 51381-78-3 6-methyl-8-nitrophenanthridine 
• 72802-34-7 guanidino4-(2-bromo-5-nitrophenyl)thiazole hydrobromide 
• 17514-60-2 ethyl 3-methyl-5-nitrobenzo[b]thiophene-2-carboxylate 
• 149914-98-7 2’-bromo-5’-amino-acetophenone 

Relevant articles and documents

A Serendipitous One-Pot Cyanation/Hydrolysis/Enamide Formation: Direct Access to 3-Methyleneisoindolin-1-ones

A direct, one-pot conversion of 2’-haloacetophenones to 3-methyleneisoindolin-1-one scaffolds using CuCN as the sole reagent without the need for moisture-free or anaerobic conditions is reported. This serendipitously discovered transformation with a broa

HETEROCYCLIC COMPOUNDS, PREPARATION METHODS THEREFOR, AND METHODS OF USES THEREOF

Provided herein are novel heterocyclic compounds, for example, compounds having Formula I. Also provided herein are methods of preparing the compounds and methods of using the same, for example, in inhibiting TGF-beta mediated signaling and/or for treating cancer.

Expanding the palette of phenanthridinium cations

5,6-Disubstituted phenanthridinium cations have a range of redox, fluorescence and biological properties. Some properties rely on phenanthridiniums intercalating into DNA, but the use of these cations as exomarkers for the reactive oxygen species (ROS), superoxide, and as inhibitors of acetylcholine esterase (AChE) do not require intercalation. A versatile modular synthesis of 5,6-disubstituted phenanthridiniums that introduces diversity by Suzuki-Miyaura coupling, imine formation and microwave-assisted cyclisation is presented. Computational modelling at the density functional theory (DFT) level reveals that the novel displacement of the aryl halide by an acyclic N-alkylimine proceeds by an SNAr mechanism rather than electrocyclisation. It is found that the displacement of halide is concerted and there is no stable Meisenheimer intermediate, provided the calculations consistently use a polarisable solvent model and a diffuse basis set.