65171-00-8

Basic information

• Product Name: [1,1'-Biphenyl]-2,2'-dicarboxaldehyde, 4,4',5,5',6,6'-hexamethoxy-
• Synonyms: [1,1'-Biphenyl]-2,2'-dicarboxaldehyde, 4,4',5,5',6,6'-hexamethoxy-
• CAS NO: 65171-00-8
• Molecular Formula: C20H22O8
• Molecular Weight: 390.39
• Mol File: 65171-00-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: [1,1'-Biphenyl]-2,2'-dicarboxaldehyde, 4,4',5,5',6,6'-hexamethoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: [1,1'-Biphenyl]-2,2'-dicarboxaldehyde, 4,4',5,5',6,6'-hexamethoxy-(65171-00-8)
• EPA Substance Registry System: [1,1'-Biphenyl]-2,2'-dicarboxaldehyde, 4,4',5,5',6,6'-hexamethoxy-(65171-00-8)

Safety Data

• Hazardous Substances Data: 65171-00-8(Hazardous Substances Data)

Upstream product

• 35274-53-4 2-bromo-3,4,5-tri-methoxybenzaldehyde 
• 15930-53-7 6-bromo-3,4-methylenedioxybenzaldehyde 
• 61441-09-6 methyl 6-bromo-1,3-benzodioxole-5-carboxylate 

Downstream Products

• 141082-08-8 (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid 6'-hydroxy-4,5,6,2',3',4'-hexamethoxy-biphenyl-2-yl ester 

Relevant articles and documents

Nickel-catalyzed asymmetric Ullmann Coupling for the synthesis of axially chiral tetra-ortho-substituted biaryl dials

(Figure Presented) The first example of nickel-catalyzed asymmetric Ullmann coupling of bls-ortho-substltuted arylhalldes is described. With the chlral BINOLbased monodentate phosphoramldite ligand, the reaction allows atropoenantloselectlve synthesis of a series of axially chiral tetra-orthosubstltuted biaryl dials. By taking advantage on this asymmetric Ullman coupling as a key stereogenlc axis-forming reaction, the formal synthesis of (+)-isoschizandrin was accomplished.

CHEMICAL COMPOUNDS

A compound of formula (I) is described; wherein the substituents are as defined in the text and wherein the compound is intended for use in the production of a vascular damaging effect in a warm-blooded animal.

SYNTHESES TOTALES ET ETUDES DE LIGNANES BIOLOGIQUEMENT ACTIFS-I. APPLICATION DE LA REACTION D'ULLMANN A LA SYNTHESE DE BIARYLES PRECURSEURS DE LIGNANES BISBENZOCYCLOOCTADIENES

Several biaryls bearing various substituents on both rings were synthesized in a preparativ fashion, and in yields up to 88percent by a technical improvement on the classical Ullmann reaction.All these biaryls bear reactive functional groups (i.e. formyl, methoxycarbonyl, dimethoxycarbonylpropyl and butanolidylmethyl) in both the o and o' positions.The biaryls 9, 13, 21 and 26-33 are plausible synthons for bisbenzocyclooctadiene lignans such as schizandrin and steganacin.