65195-61-1

Basic information

• Product Name: AKOS BC-0154
• Synonyms: AKOS BC-0154;(2-Methoxyphenyl)cyanamide
• CAS NO: 65195-61-1
• Molecular Formula: C₈H₈N₂O
• Molecular Weight: 148.16192
• Mol File: 65195-61-1.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: AKOS BC-0154(CAS DataBase Reference)
• NIST Chemistry Reference: AKOS BC-0154(65195-61-1)
• EPA Substance Registry System: AKOS BC-0154(65195-61-1)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 65195-61-1(Hazardous Substances Data)

Upstream product

• 1516-37-6 1-(2-methoxyphenyl)thiourea 
• 90-04-0 2-methoxy-phenylamine 
• 506-68-3 bromocyane 
• 16518-83-5 (2-methoxy-phenyl)-selenourea 
• 14223-46-2 o-Methoxy-phenylisoselenocyanat, o-Methoxy-phenylselenosenfoel 
• 5720-06-9 2-Methoxyphenylboronic acid 

Downstream Products

• 328540-59-6 6-chloro-2-(2-methoxyphenyl)amino-4-phenylquinazoline 
• 1174505-81-7 2-(2-methoxyanilino)-3,4-dihydroquinazolin-4-one hydrochloride 
• 75096-82-1 2-(2-methoxyphenylamino)-4H-1,3-benzothiazin-4-one 
• 1516-37-6 1-(2-methoxyphenyl)thiourea 
• 1308368-80-0 benzo-1,2,3-triazol-1-yl-[N-(2-methoxyphenyl)]amidine 
• 1020946-89-7 2-[(2-methoxyphenyl)amino]benzonitrile 
• 1334471-39-4 (R)-2-((2-hydroxyphenyl)amino)-5,5-dimethyl-4,5-dihydrothiazole-4-carboxylic acid 

Relevant articles and documents

METHODS OF TREATING PAIN WITH A THIAZOLINE ANTI-HYPERALGESIC

Methods of treating diabetic neuropathic pain and post-surgical pain are provided. The methods include administering to an individual a therapeutically effective amount of a compound of Formula I (Compound 1). The method can be used to treat diabetic neuropathy arising from any type of nerve damage, and can also be used to treat post-surgical pain arising from any surgical procedure without the side effects associated with widely used analgesics such as opioids. Compound 1 can be formulated into many suitable dosage forms, including oral dosage forms such as tablets.

A Metal and Base-Free Chemoselective Primary Amination of Boronic Acids Using Cyanamidyl/Arylcyanamidyl Radical as Aminating Species: Synthesis and Mechanistic Studies by Density Functional Theory

An efficient, metal and base-free, chemoselective synthesis of aryl-, heteroaryl-, and alkyl primary amines from the corresponding boronic acids has been achieved at ambient temperature mediated by [bis(trifluoroacetoxy)iodo]benzene (PIFA) and N-bromosuccinimide (NBS) using cyanamidyl/arylcyanamidyl radicals as the aminating species. The primary amine compounds were initially obtained as their corresponding ammonium trifluoroacetate salts which, on treatment with aq NaOH, provide the free amines. Finally, the primary amines were isolated through column chromatography over silica-gel using hexane-EtOAc solvent system as the eluent. The reactions are sufficiently fast, completing within 1 h. Quantum chemical calculations in combination with experimental observations validate that the ipso amination of substituted boronic acids involves the formation of cyanamidyl/arylcyanamidyl radical, followed by regiospecific interaction of its nitrile-N center with boron atom of the boronic acids, leading to chemoselective primary amination.

Aminocyanation by the addition of N-CN bonds to arynes: Chemoselective synthesis of 1,2-bifunctional aminobenzonitriles

An efficient aminocyanation by the direct addition of aryl cyanamides to arynes is described, enabling incorporation of highly useful amino and cyano groups synchronously via cleavage of inert N-CN bonds, affording synthetically useful 1,2-bifunctional aminobenzonitriles. The postsynthetic functionalization of the aminocyanation products allows diverse formation of synthetically important derivatives such as drug molecule Ponstan and fused heterocycles.