65423-44-1Relevant articles and documents
trans-2,5-Dialkylpyrrolidinyl-containing phosphinamines. Synthetic and mechanistic studies in Pd-catalysed asymmetric allylic alkylation
Cahill, John P.,Cunneen, Deirdre,Guiry, Patrick J.
, p. 4157 - 4173 (1999)
The preparation of new phosphinamine ligands possessing an enantiopure trans-2,5-dialkylpyrrolidinyl unit linked by a rigid o-phenylene bridge to a diphenylphosphine is described. Only that route forming the trans-2,5- dialkylpyrrolidine in the final step from (2-aminophenyl)diphenylphosphine proved successful. The cyclocondensation proceeded in 48% and 27% yields, respectively, for the dimethyl- and diethyl-analogues. Their palladium complexes were prepared and applied to the test of enantioselective alkylation of 1,3-diphenyl-2-propenyl acetate with dimethyl malonate in high chemical yields but with moderate enantioselectivities of up to 34% ee. 1H NMR spectra of the η3-allyl Pd complexes of four trans-2,5- dialkylpyrrolidine-containing ligands were analysed in an attempt to explain the results obtained. In the cases of the 1,3-diphenylallyl complexes, two diastereomers were observed for all four ligands and their configurations were assigned with the aid of COSY and NOESY experiments. The catalytic results obtained are best interpreted by the reaction proceeding with nucleophilic attack on the allyl trans to the phosphorus donor atom of the major diastereomer.
Synthesis and biological evaluation of vanadium complexes as novel anti-tumor agents
Lu, Ling-Pan,Suo, Feng-Zhi,Feng, Ya-Li,Song, Li-Li,Li, Ying,Li, Yang-Jie,Wang, Kai-Ti
, p. 1 - 10 (2019/05/15)
A class of vanadium complexes were prepared and investigated for their antiproliferative effects by MTT assay. The structure-activity relationship was extensively studied through the ligand variation. The results showed that the synthetic vanadium complexes demonstrated moderate to good antiproliferative activities against the four cancer cell lines including MGC803, EC109, MCF7 and HepG2, respectively. Of note was that most of the complexes showed preferential growth inhibitory activity to some degree toward gastric cancer line MGC803. Among them, complex 19 exhibited the most and broad-spectrum proliferative inhibition against the tested cell lines. In addition, mechanism studies illustrated that complex 19 could prevent the colony formation, migration and EMT process, as well as induce apoptosis of MGC803 cells. Furthermore, Western blot experiments revealed that the expression of apoptosis-related proteins changed, including up-regulation of Bax, PARP and caspase-3/9, as well as down-regulation of Bcl-2.
Imine compound, novel catalyst for olefin polymerization, and method for producing olefin polymer
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Paragraph 0208; 0210, (2016/10/09)
Disclosed is a compound represented by the following general formula (1). In the formula, X represents a nitrogen atom, Y represents a nitrogen atom or a phosphorous atom, R5 and R6 independently represent C1-30 hydrocarbon groups which may contain a hydrogen atom or a hetero atom, and at least one of R5 and R6 is a hydrocarbon group having two or more hetero atom-containing groups, and R1 to R4 independently represent a hydrogen atom, a halogen atom or a C1-20 hydrocarbon group which may contain a hetero atom. A plurality of groups selected from the R1 to the R4 may be connected with one another to form aliphatic rings, aromatic rings or heterocycles containing hetero atoms selected from oxygen, nitrogen and sulfur. At the time, the number of ring members is 5-8, and the ring may have a substituent.
