65427-54-5 Usage
Description
DL-2,4-DIAMINOBUTYRIC ACID DIHYDROCHLORIDE is a chemical compound with the molecular formula C4H10N2O2·2HCl. It is a white crystalline solid that is soluble in water and slightly soluble in ethanol. DL-2,4-DIAMINOBUTYRIC ACID DIHYDROCHLORIDE is an analog of the naturally occurring amino acid, L-2,4-diaminobutyric acid, and is commonly used in various applications due to its unique properties.
Uses
Used in Pharmaceutical Industry:
DL-2,4-DIAMINOBUTYRIC ACID DIHYDROCHLORIDE is used as an inhibitor of GABA transaminase, an enzyme involved in the metabolism of the neurotransmitter gamma-aminobutyric acid (GABA). By inhibiting this enzyme, the compound leads to an elevation of GABA levels in the brain, which can have potential therapeutic effects in treating neurological disorders associated with GABA deficiency.
Used in Anticancer Research:
DL-2,4-DIAMINOBUTYRIC ACID DIHYDROCHLORIDE has demonstrated antitumor activity in both in vitro and in vivo studies against mouse fibrosarcoma cells. Its potential as an anticancer agent is currently being investigated, and it may be used in the development of new cancer therapies in the future.
Used in Amino Acid Analysis:
DL-2,4-DIAMINOBUTYRIC ACID DIHYDROCHLORIDE is also used as an internal standard in amino acid analysis. It helps to ensure the accuracy and reproducibility of amino acid measurements in various biological samples, such as proteins, peptides, and other biomolecules.
Biochem/physiol Actions
DL-2,4-Diaminobutyric acid is a racemic mixture of the selective GABA uptake inhibitors L-DABA and D-DABA. DL-2,4-diaminobutyric acid is found in cell-wall peptidoglycan of Leifsonia bigeumensis sp. Nov.
Check Digit Verification of cas no
The CAS Registry Mumber 65427-54-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,5,4,2 and 7 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 65427-54:
(7*6)+(6*5)+(5*4)+(4*2)+(3*7)+(2*5)+(1*4)=135
135 % 10 = 5
So 65427-54-5 is a valid CAS Registry Number.
InChI:InChI=1/C4H10N2O2/c5-2-1-3(6)4(7)8/h3H,1-2,5-6H2,(H,7,8)/p+1/t3-/m1/s1
65427-54-5Relevant articles and documents
Preparation of enantiopure 2-acylazetidines and their reactions with chloroformates
Ma, Sang-ho,Yoon, Doo Ha,Ha, Hyun-Joon,Lee, Won Koo
, p. 269 - 271 (2007/10/03)
Enantiopure 1-phenylethylazetidine-2-carboxylates and 2-acylazetidines were prepared and reacted with chloroformates to yield α-chloro-γ-amino butyric acid esters and ketones from ring opening reaction of azetidinium ion intermediate in a completely regio- and stereoselective manner.
ENANTIOSELECTIVE SYNTHESIS OF OPTICALLY PURE NATURAL S(+) OR UNNATURAL R(-) DABA
Solladie-Cavallo, A.,Simon, M. C.
, p. 6011 - 6014 (2007/10/02)
After optimization of the reaction conditions, optically pure S(+) DABA is obtained in more than 80percent overall yield.A modell is proposed to explain the dependence of asymmetric induction on the nature of the counter ion (Li(1+), Mg(2+), Bu4N(1+)).
