65564-05-8Relevant articles and documents
Fmox: A base-labile aldehyde protecting group
Diness, Frederik,Meldal, Morten
, p. 1433 - 1436 (2015)
A base-labile aldehyde protecting group founded upon the 3-Fmoc-(1,3)-oxazinane moiety has been developed. A series of novel or previously described acid-labile aldehyde protecting groups were proven to be fully stable under the mild basic conditions, which completely removed the new base-labile aldehyde protecting group. The possible reaction pathways for introducing and removing the different aldehyde protecting groups have been explored and characterized.
IRAK DEGRADERS AND USES THEREOF
-
Paragraph 00962; 004751-004753, (2020/06/19)
The present invention provides compounds, compositions thereof, and methods of using the same.
Unexpected Acetylation of Endogenous Aliphatic Amines by Arylamine N-Acetyltransferase NAT2
Bergdahl, Ingvar A.,Conway, Louis P.,Correia, Mário S. P.,Globisch, Daniel,Rendo, Veronica,Sj?blom, Tobias
supporting information, p. 14342 - 14346 (2020/07/13)
N-Acetyltransferases play critical roles in the deactivation and clearance of xenobiotics, including clinical drugs. NAT2 has been classified as an arylamine N-acetyltransferase that mainly converts aromatic amines, hydroxylamines, and hydrazines. Herein, we demonstrate that the human arylamine N-acetyltransferase NAT2 also acetylates aliphatic endogenous amines. Metabolomic analysis and chemical synthesis revealed increased intracellular concentrations of mono- and diacetylated spermidine in human cell lines expressing the rapid compared to the slow acetylator NAT2 phenotype. The regioselective N8-acetylation of monoacetylated spermidine by NAT2 answers the long-standing question of the source of diacetylspermidine. We also identified selective acetylation of structurally diverse alkylamine-containing drugs by NAT2, which may contribute to variations in patient responses. The results demonstrate a previously unknown functionality and potential regulatory role for NAT2, and we suggest that this enzyme should be considered for re-classification.