65645-32-1

Basic information

• Product Name: Benzenemethanamine, 4-amino-α-methyl-, (αR)-
• Synonyms: Benzenemethanamine, 4-amino-α-methyl-, (αR)-;(R)-4-(1-Aminoethyl)benzenamine dihydrochloride;R-(+)-a-Methyl-p-aminobenzylamine;(R)-4-(1-AMINOETHYL)BENZENAMINE-2HCl;4-aMino-a-Methyl-;(R)-4-(1-AMinoethyl)aniline dihydrochloride;4-[(1R)-1-Aminoethyl]aniline;(R)-4-(1-Amino-ethyl)-phenylamine
• CAS NO: 65645-32-1
• Molecular Formula: C₈H₁₂N₂
• Molecular Weight: 136.197
• Mol File: 65645-32-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 269.7±15.0 °C(Predicted)
• Appearance: /
• Density: 1.056±0.06 g/cm3(Predicted)
• PKA: 9.66±0.10(Predicted)
• CAS DataBase Reference: Benzenemethanamine, 4-amino-α-methyl-, (αR)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanamine, 4-amino-α-methyl-, (αR)-(65645-32-1)
• EPA Substance Registry System: Benzenemethanamine, 4-amino-α-methyl-, (αR)-(65645-32-1)

Safety Data

• Hazardous Substances Data: 65645-32-1(Hazardous Substances Data)

Usage

General Description

Benzenemethanamine, 4-amino-α-methyl-, (αR)-, also known as L-ephedrine, is a synthetic organic compound with a chemical structure similar to methamphetamine and amphetamine. It is commonly used as a decongestant and bronchodilator in the treatment of asthma and other respiratory conditions. L-ephedrine works by stimulating the alpha and beta adrenergic receptors, leading to the relaxation of smooth muscle in the airways and the constriction of blood vessels. It can also stimulate the central nervous system, leading to increased alertness and energy. However, L-ephedrine can also have side effects such as increased heart rate, elevated blood pressure, and nervousness, and it is regulated in many countries due to its potential for abuse and dependence.

Upstream product

• 262368-44-5 (R)-[1-(4-aminophenyl)ethyl]carbamic acid tert-butyl ester 
• 57233-86-0 d-(+)-α-methyl-4-nitrobenzylamine hydrochloride 
• 694529-38-9 (R)-[1-(4-nitrophenyl)ethyl]carbamic acid t-butyl ester 
• 4187-53-5 (R)-2-methyl-p-nitrobenzylamine 
• 132873-57-5 R-alpha-methyl-4-nitrobenzylamine hydrochloride 

Downstream Products

• 694529-17-4 N-(4-t-butylbenzyl)-N'-[(1R)-1-(4-aminophenyl)ethyl]thiourea 
• 926018-36-2 C₁₆H₂₅N₃O₃ 

Relevant articles and documents

COMPOUNDS FOR THE TREATMENT OF ALZHEIMER'S DISEASE

The invention relates to substituted 1,2-ethylenediamines of general formula (I), wherein the radicals R1-R13, A, B, L and i are as defined in the description and in the claims. The invention also relates to the use thereof for treat

Chain-branched 1,3-dibenzylthioureas as vanilloid receptor 1 antagonists

A series of chain-branched 1,3-dibenzylthiourea derivatives were synthesized, and tested their antagonist activity against vanilloid receptor 1. Chain-branching led to a significant change in the mode of action and the potency. (R)-Methyl or ethyl-branched 1,3-dibenzylthiourea derivatives showed the most potent antagonist activity up to the IC50 value of 0.05 μM which is 10-fold more potent than capsazepine.