657-06-7 Usage
Description
2-Chloro-5-(trifluoromethyl)benzoic acid is an organic compound characterized by the presence of a chloro and trifluoromethyl group attached to a benzene ring, with a carboxylic acid functional group. It is a derivative of benzoic acid and possesses unique chemical properties due to the presence of the trifluoromethyl group, which imparts increased lipophilicity and metabolic stability.
Uses
Used in Environmental and Occupational Health Research:
2-Chloro-5-(trifluoromethyl)benzoic acid is used as a surrogate standard for assessing pesticide exposure and household contamination. This application is particularly relevant in the context of agricultural settings, where farmers may be at risk of exposure to various pesticides.
In this role, 2-Chloro-5-(trifluoromethyl)benzoic acid aids researchers and health professionals in:
1. Monitoring pesticide residues in urine and hand wipe samples collected from farmers, providing insights into the extent of exposure to potentially harmful chemicals.
2. Evaluating the effectiveness of safety measures and personal protective equipment in reducing pesticide exposure among agricultural workers.
3. Investigating the potential health risks associated with long-term exposure to pesticides and the presence of pesticide residues in the home environment.
The use of 2-Chloro-5-(trifluoromethyl)benzoic acid as a surrogate standard allows for a more accurate and reliable assessment of pesticide exposure levels, contributing to the development of strategies to minimize health risks and improve the safety of the agricultural workforce.
Check Digit Verification of cas no
The CAS Registry Mumber 657-06-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,5 and 7 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 657-06:
(5*6)+(4*5)+(3*7)+(2*0)+(1*6)=77
77 % 10 = 7
So 657-06-7 is a valid CAS Registry Number.
InChI:InChI=1/C8H4ClF3O2/c9-6-2-1-4(8(10,11)12)3-5(6)7(13)14/h1-3H,(H,13,14)
657-06-7Relevant articles and documents
Flow carbonylation of sterically hindered ortho-substituted iodoarenes
Mallia, Carl J.,Walter, Gary C.,Baxendale, Ian R.
supporting information, p. 1503 - 1511 (2016/08/02)
The flow synthesis of ortho-substituted carboxylic acids, using carbon monoxide gas, has been studied for a number of substrates. The optimised conditions make use of a simple catalyst system compromising of triphenylphosphine as the ligand and palladium acetate as the pre-catalyst. Carbon monoxide was introduced via a reverse "tube-in-tube" flow reactor at elevated pressures to give yields of carboxylated products that are much higher than those obtained under normal batch conditions.
Benzothiazinone compounds and their use as anti-tuberculosis agents
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Page/Page column 6, (2012/07/03)
Novel benzothiazinone derivatives of formula (I) or a pharmaceutically acceptable salt or solvate thereof have been found to be effective against Mycobacterium tuberculosis strains and may thus be useful in the treatment of tuberculosis
HSP INDUCTOR
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, (2008/06/13)
An agent for inducing HSP, comprising a compound represented by the formula (I): ???wherein R1 is a hydrogen atom, a hydrocarbon group which may be substituted, etc.; R2 is absent, a hydrogen atom or a hydrocarbon group which maybe substituted; R3 is a heterocyclic group which may be substituted; X, Y and Z are, respectively, a hydrogen, a halogen, a nitrile, a hydrocarbon group which may be substituted, or X and Y may bind to each other to form ring A, or Y and Z may bind to each other to form ring B; bond portions indicated by a solid line and a broken line are, respectively, a single bond or a double bond, and bond portions indicated by a broken line are, respectively, a single bond or absent; ring A is a homocyclic or heterocyclic 5- to 7-membered ring which may be substituted; ring B is a homocyclic or heterocyclic 5- to 7-membered ring which may be substituted; and n is an integer of 0 or 1, or a salt thereof;
