6575-24-2 Usage
Description
2,6-Dichlorophenylacetic acid is a white crystalline powder that belongs to the class of phenylacetate derivatives. It is known for its inhibitory effects on specific enzymes and its cytostatic activity against tumor cells.
Uses
Used in Pharmaceutical Industry:
2,6-Dichlorophenylacetic acid is used as an enzyme inhibitor for isopenicillin N synthase (IPNS) and acyl-CoA: 6-APA acyltransferase, playing a crucial role in the synthesis of certain antibiotics.
Used in Oncology:
2,6-Dichlorophenylacetic acid is used as a cytostatic agent for its activity against tumor cells. It is particularly effective in inhibiting the growth of cancer cells, making it a valuable compound in the development of cancer treatments.
Used in Chemical Research:
Due to its unique chemical properties and enzyme-inhibiting capabilities, 2,6-Dichlorophenylacetic acid is also used as a research compound in various scientific studies, contributing to the advancement of knowledge in biochemistry and pharmacology.
Purification Methods
Crystallise the acid from aqueous EtOH. [Beilstein 9 III 2272.]
Check Digit Verification of cas no
The CAS Registry Mumber 6575-24-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,5,7 and 5 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 6575-24:
(6*6)+(5*5)+(4*7)+(3*5)+(2*2)+(1*4)=112
112 % 10 = 2
So 6575-24-2 is a valid CAS Registry Number.
InChI:InChI=1/C8H6Cl2O2/c9-6-2-1-3-7(10)5(6)4-8(11)12/h1-3H,4H2,(H,11,12)/p-1
6575-24-2Relevant articles and documents
Liehr,Mc Closkey
, p. 491,492 (1974)
Simple and convenient preparation method of 2,6-dichlorophenylacetic acid
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Paragraph 0048-0059, (2019/06/08)
The invention provides a simple and convenient preparation method of 2,6-dichlorophenylacetic acid. By using the method, cyclohexanone is used as initial raw materials; chlorination reaction is performed with chlorination reagents to prepare 2,2,6,6-tetrachlorocyclohexanone; then, ethyl malonate condensation and hydrogen chloride removal are performed under the basic conditions, hydrolysis and rearrangement; the 2,6-dichlorophenylacetic acid is prepared through acidification decarboxylation. The used raw materials are cheap and can be easily obtained; the operation is safe, simple and convenient; the waste water quantity is small; the process achieves green and environmental-friendly effects; the product yield and the purity are high; the cost is low.
A high-throughput screening method for determining the substrate scope of nitrilases
Black, Gary W.,Brown, Nicola L.,Perry, Justin J. B.,Randall, P. David,Turnbull, Graeme,Zhang, Meng
supporting information, p. 2660 - 2662 (2015/03/05)
Nitrile compounds are intermediates in the synthesis of pharmaceuticals such as atorvastatin. We have developed a chromogenic reagent to screen for nitrilase activity as an alternative to Nessler's reagent. It produces a semi-quantifiable blue colour and hydrolysis of 38 nitrile substrates by 23 nitrilases as cell-free extracts has been shown. This journal is