658-98-0

Basic information

• Product Name: 3-Chloro-4-Fluorobenzyl Cyanide
• Synonyms: 3-CHLORO-4-FLUOROBENZYL CYANIDE;3-Chloro-4-fluorophenylacetonitrile;2-(3-chloro-4-fluorophenyl)acetonitrile;3-Chloro-4-fluoro benzeneacetonitrile;3-Chloro-4-fluorobenzyl cyanide, 2-(3-Chloro-4-fluorophenyl)ethanonitrile;Benzeneacetonitrile,3-chloro-4-fluoro-
• CAS NO: 658-98-0
• Molecular Formula: C₈H₅ClFN
• Molecular Weight: 169.58
• Product Categories: Fluorine series
• Mol File: 658-98-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 262 °C at 760 mmHg
• Flash Point: 112.3 °C
• Appearance: /
• Density: 1.286 g/cm³
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-Chloro-4-Fluorobenzyl Cyanide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Chloro-4-Fluorobenzyl Cyanide(658-98-0)
• EPA Substance Registry System: 3-Chloro-4-Fluorobenzyl Cyanide(658-98-0)

Safety Data

• HazardClass: TOXIC
• Hazardous Substances Data: 658-98-0(Hazardous Substances Data)

Usage

Chemical Properties

White crystalline powder

Upstream product

• 2994-69-6 2-chloro-4-(chloromethyl)-1-fluorobenzene 
• 151-50-8 potassium cyanide 
• 348-51-6 1-chloro-2-fluorobenzene 
• 773837-37-9 sodium cyanide 
• 192702-01-5 3-chloro-4-fluorobenzyl bromide 
• 161446-90-8 3-chloro-4-fluorobenzyl alcohol 
• 7677-24-9 trimethylsilyl cyanide 

Downstream Products

• 705-79-3 2-(3-chloro-4-fluorophenyl)acetic acid 
• 2993-87-5 3-Hydroxy-2-<4-fluor-3-chlor-phenyl>-crotonsaeure-nitril 
• 244194-67-0 2-(3-chloro-4-fluoro-phenyl)-ethylamine 
• 1205640-59-0 1-(3-chloro-4-fluorophenyl)-cyclopropanecarbonitrile 
• 1034286-79-7 2-(3-chloro-4-fluorophenyl)-4,4,4-trifluoro-3-oxobutanenitrile 
• 1231957-81-5 2-(3-chloro-4-fluorophenyl)-4-(tetrahydro-2H-pyran-2-yloxy)butanenitrile 
• 944352-60-7 C₁₃H₁₃ClFN 
• 1318756-45-4 N-[2-(3-chloro-4-fluorobenzyl)-4-methyl-1,3-thiazol-5-yl]-1-methyl-1H-pyrazole-5-carboxamide 
• 1318757-76-4 ethyl 2-(3-chloro-4-fluorobenzyl)-4-methyl-1,3-thiazole-5-carboxylate 
• 1318757-77-5 2-(3-chloro-4-fluorobenzyl)-4-methyl-1,3-thiazole-5-carboxylic acid 
• 1318757-78-6 tert-butyl [2-(3-chloro-4-fluorobenzyl)-4-methyl-1,3-thiazol-5-yl]carbamate 
• 1440519-55-0 N-[2-(3-chloro-4-fluoro-phenyl)-ethyl]-2,2,2-trifluoro-acetamide 
• 1432051-10-9 1-(3-chloro-4-fluorophenyl)-3-hydroxycyclobutanecarbonitrile 
• 1432051-09-6 [2-(3-chloro-4-fluorophenyl)-5,8-dioxaspiro[3.4]oct-2-yl](pyridin-2-yl)-methanol 

Relevant articles and documents

Discovery of 3-Pyridyl Isoindolin-1-one Derivatives as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors

Aldosterone synthase (CYP11B2) inhibitors have been explored in recent years as an alternative therapeutic option to mineralocorticoid receptor (MR) antagonists to reduce elevated aldosterone levels, which are associated with deleterious effects on various organ systems including the heart, vasculature, kidney, and central nervous system (CNS). A benzamide pyridine hit derived from a focused screen was successfully developed into a series of potent and selective 3-pyridyl isoindolin-1-ones CYP11B2 inhibitors. Our systematic structure-activity relationship study enabled us to identify unique structural features that result in high selectivity against the closely homologous cortisol synthase (CYP11B1). We evaluated advanced lead molecules, exemplified by compound 52, in an in vivo cynomolgus monkey acute adrenocorticotropic hormone (ACTH) challenge model and demonstrated a superior 100-fold in vivo selectivity against CYP11B1.

QUATERNARY PIPERIDINE DERIVATIVES AND USES THEREOF

This invention generally relates to quaternary piperidine compounds, particularly substituted 3-phenylpiperidine compounds and salts thereof. This invention also relates to pharmaceutical compositions comprising such a compound, uses of such a compound (including, for example, treatment methods and medicament preparations), and processes for making such a compound.