6582-56-5

Basic information

• Product Name: Methyl N-Benzylcarbamimidothioate Hydroiodide
• CAS NO: 6582-56-5
• Molecular Weight: 308.186
• Mol File: 6582-56-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Methyl N-Benzylcarbamimidothioate Hydroiodide(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl N-Benzylcarbamimidothioate Hydroiodide(6582-56-5)
• EPA Substance Registry System: Methyl N-Benzylcarbamimidothioate Hydroiodide(6582-56-5)

Safety Data

• Hazardous Substances Data: 6582-56-5(Hazardous Substances Data)

Upstream product

• 3287-99-8 benzylamine hydrochloride 
• 4921-91-9 N-benzoyl-N'-benzylthiourea 
• 74-88-4 methyl iodide 
• 621-83-0 N-benzylthiourea 

Downstream Products

• 66497-32-3 benzyl-selenourea 
• 489426-20-2 3-benzyl-1-(tert-butoxycarbonyl)-2-methylisothiourea 
• 93103-96-9 N-Benzyl-N'-(4-bromo-benzo[b]thiophen-2-ylmethyl)-guanidine; compound with toluene-4-sulfonic acid 
• 68695-62-5 N-benzyl-S-methyl-isothiourea 
• 25709-42-6 N,N'-dibenzylguanidine 

Relevant articles and documents

Aromatic nucleophilic substitution or CuI-catalyzed coupling route to martinellic acid

Condensation of β-amino ester 8b with triflate 7 gives N-aryl amino ester 11, which is converted into 2-substituted 4-oxoquinoline 4 using an intramolecular Dieckmann reaction as the key step. CuI-mediated coupling of β-amino ester 8a with 1,4-diiodobenzene followed by an intramolecular acylation and Pd-catalyzed carbonylation provide another manner to 4. Alkylation of 4 and subsequent reductive amination deliver the cyclic imine 14, which is transformed into triamine 3 by ordinary operations. Guanylation of 3 under mild condition followed by deprotection results in the synthesis of martinellic acid 1.