65854-78-6

Basic information

• Product Name: OXAZEPAM-D5
• Synonyms: OXAZEPAM-D5;oxazepam-D5 100 ug per ml in methanol;oxazepam-phenyl-D5--dea schedule*iv item;2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-3-hydroxy-5-(phenyl-d5)-;oxazepam-d5solution;7-Chloro-1,3-dihydro-3-hydroxy-5-(phenyl-d5)-2H-1,4-benzodiazepin-2-one;7-Chloro-1,3-dihydro-3-hydroxy-5-(phenyl-d5)-;Oxazepam-d5 (CRM)
• CAS NO: 65854-78-6
• Molecular Formula: C15H6ClD5N2O2
• Molecular Weight: 291.74
• EINECS: 200-659-6
• Product Categories: Aromatics;Heterocycles;Intermediates & Fine Chemicals;Isotope Labelled Compounds;Pharmaceuticals
• Mol File: 65854-78-6.mol
• Article Data: 1

Chemical Properties

• Flash Point: 11 °C
• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: OXAZEPAM-D5(CAS DataBase Reference)
• NIST Chemistry Reference: OXAZEPAM-D5(65854-78-6)
• EPA Substance Registry System: OXAZEPAM-D5(65854-78-6)

Safety Data

• Hazard Codes: Xn,T,F
• Statements: 40-39/23/24/25-23/24/25-11
• Safety Statements: 7-16-36/37-45
• RIDADR: UN 1230 3/PG 2
• WGK Germany: 3
• RTECS: DF1400000
• Hazardous Substances Data: 65854-78-6(Hazardous Substances Data)

Usage

Description

Oxazepam-d5 is intended for use as an internal standard for the quantification of oxazepam by GC- or LC-MS. Oxazepam-d5 is an analytical reference material that is structurally categorized as a benzodiazepine. Oxazepam is an active metabolite of diazepam , prazepam, and temazepam that can positively modulate GABAA receptors, which results in inhibitory effects in the central nervous system. This product is intended for forensic and research purposes.

Uses

Labelled Oxazepam. Anxiolytic; muscle relaxant (skeletal); anticonvulsant; ligand for the GABAA receptor benzodiazepine modulatory site. Controlled substance (depressant).

Upstream product

• 65854-72-0 2-amino-5-chlorobenzophenone-2',3',4',5',6'-d5 
• 215527-70-1 2,3,4,5,6-pentadeuteriumbenzeneboronic acid 
• 719-59-5 5-chloro-2-aminobenzophenone 

Relevant articles and documents

Preparation method of stable isotope labeled oxazepam internal standard reagent

The invention relates to a preparation method of a stable isotope labeled oxazepam internal standard reagent for monitoring the blood concentration of clinical treatment drugs, and belongs to the field of research and development of standard substances for monitoring clinical treatment drugs. The stable isotope labeled oxazepam is obtained by taking stable isotope labeled phenylboronic acid as a raw material through catalytic addition, acylation, cyclization, acetylation, hydrolysis and final separation and purification. The process has the advantages that raw materials needed for synthesis are simple and easy to obtain, reaction conditions are mild, the chemical purity of the target product stable isotope labeled oxazepam can reach 98% or above, the isotope abundance can reach 98% or above, and the preparation method can meet the technical requirements of a stable isotope labeled internal standard reagent needed by a clinical drug monitoring liquid chromatography-tandem mass spectrometry method.