65858-50-6

Basic information

• Product Name: 5-(BROMOMETHYL)-2,1,3-BENZOTHIADIAZOLE
• Synonyms: 5-(Bromomethyl)-2,1,3-benzothiadiazole, 95+%;5-(bromomethyl)benzo[c][1,2,5]thiadiazole;5-(BroMoMethyl)benzo-2,1,3-thiadiazole;2,1,3-Benzothiadiazole, 5-bromomethyl-;5-(bromomethyl)piazthiole;5-Bromomethyl-benzo[1,2,5]thiadiazole;6-(bromomethyl)-2,1,3-benzothiadiazole;5-(BROMOMETHYL)-2,1,3-BENZOTHIADIAZOLE
• CAS NO: 65858-50-6
• Molecular Formula: C₇H₅BrN₂S
• Molecular Weight: 229.1
• Mol File: 65858-50-6.mol
• Article Data: 9

Chemical Properties

• Melting Point: 91 °C
• Boiling Point: 299.3°C at 760 mmHg
• Flash Point: 134.8°C
• Appearance: /
• Density: 1.776g/cm³
• Vapor Pressure: 0.00214mmHg at 25°C
• Refractive Index: 1.726
• PKA: -0.29±0.36(Predicted)
• CAS DataBase Reference: 5-(BROMOMETHYL)-2,1,3-BENZOTHIADIAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(BROMOMETHYL)-2,1,3-BENZOTHIADIAZOLE(65858-50-6)
• EPA Substance Registry System: 5-(BROMOMETHYL)-2,1,3-BENZOTHIADIAZOLE(65858-50-6)

Safety Data

• Hazard Codes: C
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 65858-50-6(Hazardous Substances Data)

Usage

General Description

5-(Bromomethyl)-2,1,3-benzothiadiazole is a chemical compound with the molecular formula C8H5BrN2S. It falls under the category of benzothiadiazoles, which are aromatic compounds involving a benzene ring fused with a thiadiazole ring. The presence of a bromomethyl group (-CH2Br) further classifies the compound. The specific nature and arrangement of these rings and groups grant this compound with unique physical and chemical properties. Its applications can be found in various fields like organic synthesis, pharmaceuticals, and materials science, often being used as an intermediate or a building block in the formulation of more complex molecules. Detailed understanding of the substance's influences on health and environment and its complete physical and chemical properties require further research and scrutiny.

InChI:InChI=1/C7H5BrN2S/c8-4-5-1-2-6-7(3-5)10-11-9-6/h1-3H,4H2

Upstream product

• 1457-93-8 5-methylbenzo[c][1,2,5]thiadiazole 
• 34241-39-9 azobisisobutyronitrile 
• 103-89-9 4-Methylacetanilide 
• 106-49-0 p-toluidine 
• 612-45-3 4-methyl-2-nitroacetanilide 
• 89-62-3 4-methyl-2-nitroaniline 
• 496-72-0 4-methyl-1,2-diaminobenzene 

Downstream Products

• 74375-65-8 C-benzo[1,2,5]thiadiazol-5-yl-methylamine; hydrochloride 
• 89899-11-6 2-(benzo[c][1,2,5]thiadiazol-5-yl)acetonitrile 
• 89795-51-7 2,1,3-benzothiadiazol-5-ylmethanol 
• 71605-72-6 benzo[c][1,2,5]thiadiazole-5-carbaldehyde 
• 16405-98-4 benzo[c][1,2,5]thiadiazole-5-carboxylic acid 
• 71605-71-5 N'-benzo[1,2,5]thiadiazol-5-ylmethylene-N,N-dimethyl-benzene-1,4-diamine N'-oxide 
• 71605-66-8 2-(benzo[1,2,5]thiadiazol-5-ylmethyl-amino)-ethanethiol 
• 71605-70-4 5-thiazolidin-2-yl-benzo[1,2,5]thiadiazole 
• 100333-42-4 5,5'-(5,6-dithia-2,9-diaza-decane-1,10-diyl)-bis-benzo[1,2,5]thiadiazole 
• 55937-37-6 (benzo[c][1,2,5]thiadiazol-5-yl)acetic acid 
• 92164-37-9 2-benzo[1,2,5]thiadiazol-5-yl-N-phenyl-acetamide 
• 74375-66-9 2,1,3-benzothiadiazol-5-ylmethanamine 
• 1043908-49-1 4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-1-(benzo[c][1,2,5]thiadiazol-5-ylmethyl)-5-methyl-3-m-tolyl-1H-imidazol-2(3H)-one 
• 1043908-60-6 4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-1-(benzo[c][1,2,5]thiadiazol-5-ylmethyl)-3-(3-chloro-4-fluorophenyl)-5-methyl-1H-imidazol-2(3H)-one 

Relevant articles and documents

Piperidine compound and preparation method and medical application thereof

The invention discloses a piperidine compound shown as a formula (I) and a preparation method and medical application thereof, and particularly relates to a piperidine USP7 inhibitor compound or pharmaceutically acceptable salt or ester or solvate thereof and a preparation method and application of the piperidine USP7 inhibitor compound or pharmaceutically acceptable salt or ester or solvate thereof. The compound provided by the invention can inhibit the activity of USP7 enzyme, has very good selectivity and druggability, and can be used for preparing medicines for preventing or treating tumor diseases or virus infectious diseases.

Biphenyl compound as well as preparation method and medical application thereof

The invention discloses a biphenyl compound as well as a preparation method and medical application thereof, the structure of the biphenyl compound is shown as a formula (I) or a formula (II), and thebiphenyl compound or pharmaceutically acceptable salt, tautomer, meso-isomer, raceme, stereoisomer, metabolite, metabolite precursor, prodrug or solvate thereof is a PD-L1 inhibitor. The compound hasa remarkable inhibiting effect on the interaction of PD-1 and PD-L1 protein, so that the compound can be applied to the preparation of PD-L1 inhibitors and immunomodulator drugs for preventing or treating tumors, autoimmune diseases, organ transplant rejection, infectious diseases and inflammatory diseases.

Endothelin antagonists benzene oxygen benzene acetic acids and its preparation method and application

The invention provides a phenoxy phenylacetic acid endothelin antagonist shown in a formula (I) or a pharmaceutically acceptable salt thereof, and also provides a preparation method of the benzene oxygen phenylacetic acid endothelin antagonist or the pharmaceutically acceptable salt thereof, and an application thereof in preparation of a medicament for treating cardiovascular and cerebrovascular diseases, tumors, diabetes mellitus, nephrosis, asthma or hyperthyroidism.