65891-80-7Relevant articles and documents
Novel method for synthesizing D5-diazepam
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, (2021/06/09)
The invention discloses a novel method for synthesizing D5-diazepam, belongs to the field of organic chemistry, and can be applied to the field of forensic poison analysis. According to the method disclosed by the invention, 2-amino-5-chlorobenzyl cyanide and D5-phenylboronic acid are used as raw materials, and the D5-diazepam is obtained by carrying out addition, cyclization and methylation processes on cyano groups by palladium-catalyzed arylboronic acid and carrying out separation and purification. The method has the advantages of mild reaction conditions, short synthesis steps, high yield and the like, and the synthesized D5-diazepam has high purity and good stability and can be used as an internal standard substance for forensic poison analysis quality control to realize domestic substitution.