659736-46-6

Basic information

• Product Name: 3',4'-DIHYDRO-6'-BROMO-SPIRO[IMIDAZOLIDINE-4,2(1'H)-NAPHTHALENE]-2,5-DIONE
• Synonyms: 3',4'-DIHYDRO-6'-BROMO-SPIRO[IMIDAZOLIDINE-4,2(1'H)-NAPHTHALENE]-2,5-DIONE;3',4'-Dihydro-6'-bromo-spiro[imidazolidine-4,2(1'H)-naphtalene]-2,5-dione, 98 %;3',4'-Dihydro-6'-bromo-spiro[imidazolidine-4,2(1'H)-naphtalene]-2,5-dione
• CAS NO: 659736-46-6
• Molecular Formula: C12H11BrN2O2
• Molecular Weight: 295.13
• Mol File: 659736-46-6.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3',4'-DIHYDRO-6'-BROMO-SPIRO[IMIDAZOLIDINE-4,2(1'H)-NAPHTHALENE]-2,5-DIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3',4'-DIHYDRO-6'-BROMO-SPIRO[IMIDAZOLIDINE-4,2(1'H)-NAPHTHALENE]-2,5-DIONE(659736-46-6)
• EPA Substance Registry System: 3',4'-DIHYDRO-6'-BROMO-SPIRO[IMIDAZOLIDINE-4,2(1'H)-NAPHTHALENE]-2,5-DIONE(659736-46-6)

Safety Data

• Hazardous Substances Data: 659736-46-6(Hazardous Substances Data)

Upstream product

• 4133-35-1 6-bromo-2-tetralone 
• 151-50-8 potassium cyanide 
• 506-87-6 ammonium carbonate 
• 37859-24-8 2-(4-bromophenyl)acetyl chloride 
• 1878-68-8 2-(4-bromophenyl)-acetic acid 
• 143-33-9 sodium cyanide 
• 773837-37-9 sodium cyanide 

Downstream Products

• 659736-91-1 2-amino-6-bromo-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid 
• 690254-43-4 methyl 2-amino-1,2,3,4-tetrahydro-6-bromo-2-naphthalenecarboxylate 
• 690254-48-9 (S)-2-(tert-butyloxycarbonyl)amino-1,2,3,4-tetrahydro-6-bromo-2-naphthalenecarboxylic acid 
• 690254-49-0 benzyl (S)-2-(tert-butyloxycarbonyl)amino-1,2,3,4-tetrahydro-6-bromo-2-naphthalenecarboxylate 

Relevant articles and documents

HETEROCYCLIC BENZODIAZEPINE CGRP RECEPTOR ANTAGONISTS

Compounds of formula I: (where variables R2, R7, D, W, X, Y and Z are as described herein) which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

SPIROHYDANTOIN ARYL CGRP RECEPTOR ANTAGONISTS

Compounds of formula (I); (wherein variables A1, A2. A3, A4, A5, A6, A7, B3 E1, E2, E3, E4, E5, G1, G2 and R.6 are as described herein) which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

TRICYCLIC ANILIDE SPIROHYDANTOIN CGRP RECEPTOR ANTAGONISTS

The present invention is directed to compounds of Formula I: I (where A1, A2, B1, B2, B3, B4, D1, D2, T, U, V, W, X, Y, Z, R4, R5a?, R5b/su