659737-57-2

Basic information

• Product Name: 1H-Isoindol-1-one, 2,3-dihydro-6-hydroxy- (9CI)
• Synonyms: 1H-Isoindol-1-one, 2,3-dihydro-6-hydroxy- (9CI);6-hydroxyisoindolin-1-one;1H-Isoindol-1-one, 2,3-dihydro-6-hydroxy-;6-Hydroxy-2,3-dihydro-1H-isoindol-1-one;6-hydroxy-1-isoindolinone
• CAS NO: 659737-57-2
• Molecular Formula: C₈H₇NO₂
• Molecular Weight: 149.14668
• Product Categories: ALCOHOL
• Mol File: 659737-57-2.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 507.336 °C at 760 mmHg
• Flash Point: 260.628 °C
• Appearance: /
• Density: 1.362 g/cm³
• Storage Temp.: 2-8°C
• PKA: 9.43±0.20(Predicted)
• CAS DataBase Reference: 1H-Isoindol-1-one, 2,3-dihydro-6-hydroxy- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Isoindol-1-one, 2,3-dihydro-6-hydroxy- (9CI)(659737-57-2)
• EPA Substance Registry System: 1H-Isoindol-1-one, 2,3-dihydro-6-hydroxy- (9CI)(659737-57-2)

Safety Data

• Hazardous Substances Data: 659737-57-2(Hazardous Substances Data)

Usage

General Description

1H-Isoindol-1-one, 2,3-dihydro-6-hydroxy- (9CI) is a specific chemical compound that is categorized under organic compounds known as isoindolones, which are compounds containing an isoindole ring with a ketone group. The compound itself features an isoindole backbone, which is considered saturated due to the presence of additional hydrogen atoms. The "6-hydroxy" part refers to the presence of a hydroxyl functional group at the sixth position in its molecular structure, contributing to its overall reactivity and behavior in chemical reactions. As a synthetic compound, it is mainly used in research and development applications, often as a reactant or a synthetic intermediate in the manufacturing of a variety of products.

Upstream product

• 22246-66-8 6-methoxy-2,3-dihydro-isoindol-1-one 
• 788081-99-2 methyl 2-(bromomethyl)-5-methoxy-benzoate 
• 73502-03-1 methyl 5-methoxy-2-methyl-benzoate 

Downstream Products

• 1138220-71-9 7-chloro-6-hydroxy-2,3-dihydroisoindol-1-one 

Relevant articles and documents

Synthesis and structure-activity relationship of novel lactam-fused chroman derivatives having dual affinity at the 5-HT1A receptor and the serotonin transporter

The structure-activity relationship (SAR) for three series of lactam-fused chroman derivatives possessing 3-amino substituents was evaluated. Many compounds exhibited affinities for both the 5-HT1A receptor and the 5-HT transporter. Compounds 45 and 53 demonstrated 5-HT1A antagonist activities in the in vitro cAMP turnover model.

HETEROCYCLIC AMIDE COMPOUNDS AS PROTEIN KINASE INHIBITORS

The present invention related to novel heterocyclic amide compounds of Formula 1: as disclosed herein or a pharmaceutically accept able salt, solvate, ester, prodrug or stereoisomer thereof. Also disclosedare compositions comprising said compounds, and methods for using said compounds for treating or preventing a proliferative disease, an anti-proliferative disorder, inflammation, arthritis, a neurological or neurodenerative disease, a cardiovascular disease, alopecia, a neuronal disease, an ischemic injury, a viral disease or a fungal disease

TRICYCLIC COMPOUNDS USEFUL AS SEROTONIN INHIBITORS AND 5-HT1A AGONISTS AND ANTAGONISTS

3-Amino chroman and 2-amino tetralin derivatives and compositions containing such compounds are disclosed. Such compounds are useful for modulating activity of a 5-HT1A receptor (agonizing or antagonizing) in a patient. These compounds are further useful for inhibiting binding to a serotonin receptor. Methods of using the 3-amino chroman and 2-amino tetralin compounds and compositions containing such compounds in the treatment of serotonin disorders, such as depression and anxiety, are also disclosed.