660395-39-1Relevant articles and documents
Lipid compound and composition thereof
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Paragraph 0209-0212, (2021/07/31)
The invention relates to a lipid compound and a composition thereof, a lipid nanoparticle containing the composition, a preparation method of the composition and application of the composition in drug delivery.
Facile Conversion of Molecularly Complex (Hetero)aryl Carboxylic Acids into Alkynes for Accelerated SAR Exploration
Lutter, Ferdinand H.,Jouffroy, Matthieu
supporting information, p. 14816 - 14820 (2021/10/08)
1,2,3-Triazoles are well-established bioisosteres for amides, often installed as a result of structure?activity-relationship (SAR) exploration. A straightforward approach to assess the effect of the replacement of an amide by a triazole would start from the carboxylic acid and the amine used for the formation of a given amide and convert them into the corresponding alkyne and azide for cyclization by copper-catalyzed alkyne?azide cycloaddition (CuAAC). Herein, we report a functional-group-tolerant and operationally simple decarbonylative alkynylation that allows the conversion of complex (hetero)aryl carboxylic acids into alkynes. Furthermore, the utility of this method was demonstrated in the preparation of a triazolo analog of the commercial drug moclobemide. Lastly, mechanistic investigations using labeled carboxylic acid derivatives clearly show the decarbonylative nature of this transformation.
COMPOUNDS AND METHODS FOR TREATING CANCER
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Paragraph 0190; 0393, (2020/12/19)
Substituted cinnamamide compounds and analogs, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds to treat, prevent or ameliorate cancer are provided.