660399-53-1Relevant articles and documents
Quinazolinones and pyrido[3,4-d]pyrimidin-4-ones as orally active and specific matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis
Jie, Jack Li,Nahra, Joe,Johnson, Adam R.,Bunker, Amy,O'Brien, Patrick,Yue, Wen-Song,Ortwine, Daniel F.,Man, Chiu-Fai,Baragi, Vijay,Kilgore, Kenneth,Dyer, Richard D.,Han, Hyo-Kyung
, p. 835 - 841 (2008)
Quinazolinones 8 and pyrido[3,4-d]pyrimidin-4-ones 9 as orally active and specific matrix metalloproteinase-13 inhibitors were discovered for the treatment of osteoarthritis. Starting from a high-through-put screening (HTS) hit thizolopyrimidin-dione 7, w
Oxo-azabicyclic compounds
-
Page column 34, (2010/02/07)
A compound selected from those of formula (I): wherein: X1, X2, and X3, represent N or —CR3in which R3is as described in the description, G1represents a group selected from those of formula