66123-43-1

Basic information

• Product Name: 4-(4-hydroxyphenyl)-4-oxobutanoic acid ethyl ester
• Synonyms: 4-(4-hydroxyphenyl)-4-oxobutanoic acid ethyl ester
• CAS NO: 66123-43-1
• Molecular Weight: 222.241
• Mol File: 66123-43-1.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 4-(4-hydroxyphenyl)-4-oxobutanoic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-hydroxyphenyl)-4-oxobutanoic acid ethyl ester(66123-43-1)
• EPA Substance Registry System: 4-(4-hydroxyphenyl)-4-oxobutanoic acid ethyl ester(66123-43-1)

Safety Data

• Hazardous Substances Data: 66123-43-1(Hazardous Substances Data)

Upstream product

• 64-17-5 ethanol 
• 56872-39-0 3-(4-hydroxybenzoyl)propionic acid 
• 100-66-3 methoxybenzene 
• 3153-44-4 4-(4-methoxy-phenyl)-4-oxo-butyric acid 
• 15118-67-9 ethyl 3-(4-methoxybenzoyl)-propionate 

Downstream Products

• 63471-88-5 4-(4-butoxy-phenyl)-4-oxo-butyric acid 
• 64779-14-2 4-(4-hexyloxy-phenyl)-4-oxo-butyric acid 
• 339289-36-0 4-(4-isopentyloxy-phenyl)-4-oxo-butyric acid 
• 1005402-75-4 4-[4-(6-oxo-1,4,5,6-tetrahydro-pyridazin-3-yl)-phenoxy]-piperidine-1-carboxylic acid tert-butyl ester 
• 1224582-49-3 C₂₀H₂₇N₃O₂ 
• 1005403-42-8 C₁₅H₁₉N₃O₂ 
• 217076-10-3 C₁₇H₂₃N₃O₂ 
• 1357019-37-4 C₁₈H₂₅N₃O₂ 
• 1367308-92-6 C₁₉H₂₇NO₄ 
• 1367309-02-1 C₂₀H₂₉NO₄ 
• 1005402-80-1 4-{4-[3-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-4-oxo-butyric acid ethyl ester 
• 119348-34-4 4-<4-<(4-acetyl-3-hydroxy-2-propylphenyl)methoxy>phenyl>-4-oxobutanoic acid 
• 94194-07-7 C₂₈H₃₈O₅ 

Relevant articles and documents

4-Phenoxypiperidine pyridazin-3-one histamine H3 receptor inverse agonists demonstrating potent and robust wake promoting activity

Structure-activity relationships for a series of phenoxypiperidine pyridazin-3-one H3R antagonists/ inverse agonists are disclosed. The search for compounds with improved hERG and DAT selectivity without the formation of in vivo active metaboli

Pyridizinone derivatives

The present invention provides compounds of formula (I*): their use as H3 inhibitors, processes for their preparation, and pharmaceutical compositions thereof.

(Phenylmethoxy)phenyl Derivatives of Ω-Oxo- and Ω-Tetrazolylalkanoic Acids and Related Tetrazoles. Synthesis and Evaluation as Leukotriene D4 Receptor Antagonists

Two series of (phenylmethoxy)phenyl compounds derived from the structure of LY163443 were synthesized and evaluated as leukotriene D4 receptor antagonists.In the Ω--Ω-oxoalkanoic acid series, 5-phenyl>-3,3-dimethyl-5-oxopentanoic acid (8) was the most potent antagonist of LTD4-induced contractions of guinea pig ileum (pKB of 7.60) and LTD4 pressor response in pithed rats (ED50 of 1.4 mg/kg iv).Replacing the carboxylic acid function with 5-tetrazole gave slightly more potent compounds.Inthe Ω-alkyl>tetrazolyl>alkanoic acid series, replacing the carboxylic acid with 5-tetrazole gave compounds that were equally effective in the guinea pig ileum but more potent in vivo against the LTD4 pressor response in rat.The pKB value in the guinea pig ileum for 1--2H-tetrazol-5-yl>methyl>phenoxy>methyl>phenyl>ethanone (25) was 7.87 and the ED50 for antagonism of the LTD4 pressor response was 4.0 mg/kg iv.The sodium salts of 8 (9) and 25(26) given by the iv route of administration antagonized LTD4-induced cardiovascular alterations in anesthetized rat and LTD4-induced bronchoconstriction in guinea pig in a dose-dependent manner.Oral activity was also demonstrated against the LTD4-induced bronchoconstriction in guinea pig.