6619-22-3Relevant articles and documents
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Spaeth,Takei,Miyajima
, p. 262 (1934)
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Synthesis and evaluation of aliphatic-chain hydroxamates capped with osthole derivatives as histone deacetylase inhibitors
Huang, Wei-Jan,Chen, Ching-Chow,Chao, Shi-Wei,Yu, Chia-Chun,Yang, Chen-Yui,Guh, Jih-Hwa,Lin, Yun-Chieh,Kuo, Chiao-I.,Yang, Ping,Chang, Chung-I.
supporting information; experimental part, p. 4042 - 4049 (2011/11/12)
Our previous studies have demonstrated that osthole, a Chinese herbal compound, could be incorporated into the hydroxycinnamide scaffold of LBH-589, a potent HDAC inhibitor, as an effective hydrophobic cap; the resulting compounds showed significant poten
Identification and structure-activity relationship studies of osthol, a cytotoxic principle from Cnidium monnieri
Hitotsuyanagi, Yukio,Kojima, Hiroshi,Ikuta, Hiroshi,Takeya, Koichi,Itokawa, Hideji
, p. 1791 - 1794 (2007/10/03)
Osthol (1) was isolated from the fruit of Cnidium monnieri as a cytotoxic principle. Its structure-activity relationship study reveals that the 3,4-olefinic bond is essential for its cytotoxic activity, and the prenyl (C5) unit attached at the 8 position enhances the cytotoxicity. Analogues 7 and 8 that have a longer alkoxy unit at the 7 position showed ten times higher cytotoxicity than 1.
