66195-39-9

Basic information

• Product Name: 2-Iodo-6-methoxybenzoic acid
• Synonyms: 2-Iodo-6-methoxybenzoic acid;6-Iodo-o-anisic acid
• CAS NO: 66195-39-9
• Molecular Formula: C₈H₇IO₃
• Molecular Weight: 278.04385
• Mol File: 66195-39-9.mol
• Article Data: 10

Chemical Properties

• Melting Point: 129-131℃
• Boiling Point: 351℃
• Flash Point: 166℃
• Appearance: /
• Density: 1.878
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 2.75±0.10(Predicted)
• CAS DataBase Reference: 2-Iodo-6-methoxybenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Iodo-6-methoxybenzoic acid(66195-39-9)
• EPA Substance Registry System: 2-Iodo-6-methoxybenzoic acid(66195-39-9)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 66195-39-9(Hazardous Substances Data)

Usage

General Description

2-iodo-6-methoxybenzoic acid is a chemical compound with the molecular formula C8H7IO3. This substance falls under the category of organic compounds known as benzoic acids, which contain a benzene ring with a carboxyl acid group attached. The primary applications of this chemical are not specifically identified, likely due to its use in various scientific research studies or as an intermediate in the preparation of other chemical substances. It's known for its reactive properties, especially considering the iodine substituent which can undergo various organic reactions. The methoxy group also provides interesting aspects of reactivity, potentially being a site for various substitution reactions. Its properties can be highly dependent on factors such as purity and handling procedures, and like many organic compounds, improper handling can result in safety risks.

Upstream product

• 5025-59-2 2-iodo-6-methoxybenzaldehyde 
• 53600-33-2 6-methoxyanthranilic acid 
• 89677-81-6 Methyl 2-hydroxy-6-iodobenzoate 
• 77-78-1 dimethyl sulfate 
• 579-75-9 2-Methoxybenzoic acid 
• 626-02-8 3-Iodophenol 
• 38169-97-0 2-hydroxy-6-iodobenzaldehyde 

Downstream Products

• 877265-22-0 (2-iodo-6-methoxyphenyl)methanol 
• 915943-50-9 1-iodo-2-iodomethyl-3-methoxy-benzene 
• 915943-54-3 1-(2-iodo-6-methoxy-benzyl)-1H-benzo[cd]indol-3-one 
• 915943-58-7 3-acetyl-1-(2-iodo-6-methoxy-benzyl)-1H-indole-4-carbaldehyde 
• 66195-40-2 2-iodo-6-methoxybenzamide 
• 5025-59-2 2-iodo-6-methoxybenzaldehyde 
• 1360789-53-2 methyl 2-hydroxy-6-iodobenzoate 
• 89677-81-6 Methyl 2-hydroxy-6-iodobenzoate 
• 830-54-6 8-methoxy-3-methyl-1H-isochromen-1-one 

Relevant articles and documents

Isocoumarin derivative as well as preparation method and medical application thereof

The invention belongs to the technical field of chemical medicines, and relates to an isocoumarin compound of general formula (I) and a preparation method and medical application, of the isocoumarin compound in preparation of medicines for treating and mo

Design, Synthesis, and Herbicidal Activity of Pyrimidine-Biphenyl Hybrids as Novel Acetohydroxyacid Synthase Inhibitors

The issue of weed resistance to acetohydroxyacid synthase (EC 2.2.1.6, AHAS) inhibitors has become one of the largest obstacles for the application of this class of herbicides. In a continuing effort to discover novel AHAS inhibitors to overcome weed resistance, a series of pyrimidine-biphenyl hybrids (4aa-bb and 5aa-ah) were designed and synthesized via a scaffold hopping strategy. Among these derivatives, compounds 4aa (Ki = 0.09 μM) and 4bb (Ki = 0.02 μM) displayed higher inhibitory activities against Arabidopsis thaliana AHAS than those of the controls bispyribac (Ki = 0.54 μM) and flumetsulam (Ki = 0.38 μM). Remarkably, compounds 4aa, 4bb, 5ah, and 5ag exhibited excellent postemergence herbicidal activity and a broad spectrum of weed control at application rates of 37.5-150 g of active ingredient (ai)/ha. Furthermore, 4aa and 4bb showed higher herbicidal activity against AHAS inhibitor-resistant Descurainia sophia, Ammannia arenaria, and the corresponding sensitive weeds than that of bispyribac at 0.94-0.235 g ai/ha. Therefore, the pyrimidine-biphenyl motif and lead compounds 4aa and 4bb have great potential for the discovery of novel AHAS inhibitors to combat AHAS-inhibiting herbicide-resistant weeds.

Asymmetric synthesis of 4,8-dihydroxyisochroman-1-one polyketide metabolites using chiral hypervalent iodine(III)

Stereoselective oxylactonization of ortho-alkenylbenzoate with chiral hypervalent iodine is applied to the asymmetric synthesis of 4-oxyisochroman-1-one polyketide metabolites including 4-hydroxymellein (1), a derivative of fusarentin 2, monocerin (3), and an epimer of monocerin epi-3.