66209-45-8

Basic information

• Product Name: Cyclobutyl-[(R)-1-(4-methoxy-benzyl)-3,4,5,6,7,8-hexahydro-1H-isoquinolin-2-yl]-methanone
• CAS NO: 66209-45-8
• Molecular Weight: 339.478
• Mol File: 66209-45-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Cyclobutyl-[(R)-1-(4-methoxy-benzyl)-3,4,5,6,7,8-hexahydro-1H-isoquinolin-2-yl]-methanone(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclobutyl-[(R)-1-(4-methoxy-benzyl)-3,4,5,6,7,8-hexahydro-1H-isoquinolin-2-yl]-methanone(66209-45-8)
• EPA Substance Registry System: Cyclobutyl-[(R)-1-(4-methoxy-benzyl)-3,4,5,6,7,8-hexahydro-1H-isoquinolin-2-yl]-methanone(66209-45-8)

Safety Data

• Hazardous Substances Data: 66209-45-8(Hazardous Substances Data)

Upstream product

• 3721-95-7 Cyclobutanecarboxylic acid 
• 93477-35-1 (+/-)-1-(4-methoxybenzyl)-1,2,3,4,5,6,7,8-octahydroisoquinoline hydrobromide 
• 38969-65-2 1-(p-methoxybenzyl)-2-methyl-1,2,3,4,5,6,7,8-octahydroisoquinoline 
• 51072-36-7 (+)-1-(p-methoxybenzyl)-1,2,3,4,5,6,7,8-octahydroisoquinoline 
• 5006-22-4 Cyclobutanecarbonyl chloride 

Relevant articles and documents

Preparation method of butorphanol tartrate and intermediate thereof

The invention provides a preparation method of butorphanol tartrate and an intermediate of butorphanol tartrate. The preparation method of the butorphanol tartrate and the intermediate of the butorphanol tartrate is mild in reaction condition, safe to operate and more suitable for large-scale production.

A stereoselective total synthesis of 14-hydroxymorphinans, Grewe approach

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Process for the preparation of 14-hydroxymorphinan derivatives

N-substituted-14-hydroxy-3-substituted-morphinan derivatives have been found to possess potent narcotic agonist or antagonist activity. In particular, the compound N-Cyclobutylmethyl-3,14-dihydroxymorphinan has been found to possess potent agonist/antagonist activity as a non-narcotic analgesic. A new and efficient total synthesis of these compounds is described herein from the starting material 2-(p-methoxybenzyl)-1,2,3,4,5,6,7,8-octahydroisoquinoline.