6627-53-8 Usage
Description
5-Chloro-2-nitroanisole is an organic compound that serves as an important intermediate in the synthesis of various pharmaceuticals, particularly in the development of anticancer drugs.
Used in Pharmaceutical Industry:
5-Chloro-2-nitroanisole is used as a key intermediate in the synthesis of orally bioavailable anaplastic lymphoma kinases (ALK) inhibitors, which are anticancer drugs designed to target and inhibit the activity of ALK enzymes, thereby suppressing tumor growth and progression (1).
Additionally, 5-chloro-2-nitroanisole is utilized in the synthesis of kinesin spindle protein (KSP) inhibitors. These inhibitors play a crucial role in disrupting the spindle pole separation that occurs during mitosis in cancer cells, thus preventing cell division and stopping the spread of cancer (2).
Check Digit Verification of cas no
The CAS Registry Mumber 6627-53-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,6,2 and 7 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 6627-53:
(6*6)+(5*6)+(4*2)+(3*7)+(2*5)+(1*3)=108
108 % 10 = 8
So 6627-53-8 is a valid CAS Registry Number.
InChI:InChI=1/C7H6ClNO3/c1-12-7-4-5(8)2-3-6(7)9(10)11/h2-4H,1H3
6627-53-8Relevant articles and documents
COMBINATION THERAPIES FOR TREATMENT OF CANCER
-
, (2016/04/09)
Combination therapies for treatment of cancers associated with mutations in the KRAS gene are provided. Compositions comprising therapeutic agents for treatment of cancers associated with mutations in the KRAS gene are also provided.
Reactions of Organic Anions, 147.- Simple and General Synthesis of Hydroxy- and Methoxyindoles via Vicarious Nucleophilic Substitution of Hydrogen
Makosza, Mieczyslaw,Danikiewicz, Witold,Wojciechowski, Krzysztof
, p. 203 - 208 (2007/10/02)
A simple synthesis of 4-, 5-, 6-, and 7-hydroxy- and -methoxyindoles via cyanoalkylation of O-protected nitrophenols by vicarious nucleophilic substitution of hydrogen, followed by catalytic hydrogenation of the (2-nitroaryl)acetonitriles obtained is described.
