6628-83-7

Basic information

• Product Name: C-(TETRAHYDRO-PYRAN-2-YL)-METHYLAMINE HYDROCHLORIDE
• Synonyms: C-(TETRAHYDRO-PYRAN-2-YL)-METHYLAMINE;C-(TETRAHYDRO-PYRAN-2-YL)-METHYLAMINE HYDROCHLORIDE;TETRAHYDROPYRAN-2-YLMETHYLAMINE;TETRAHYDRO-PYRAN-2-YLMETHYLAMINE HCL;(TETRAHYDRO-2H-PYRAN-2-YL)METHANAMINE;2-aminomethyltetrahydro-pyra;2-aminomethyltetrahydropyran;2-(Aminomethyl)tetrahydro-2H-pyran
• CAS NO: 6628-83-7
• Molecular Formula: C₆H₁₃NO
• Molecular Weight: 151.63
• Product Categories: Amines and Anilines;API intermediates
• Mol File: 6628-83-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 211.9°C (rough estimate)
• Flash Point: 64.9°C
• Appearance: /
• Density: 1.0223 (rough estimate)
• Vapor Pressure: 0.912mmHg at 25°C
• Refractive Index: 1.4210 (estimate)
• CAS DataBase Reference: C-(TETRAHYDRO-PYRAN-2-YL)-METHYLAMINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: C-(TETRAHYDRO-PYRAN-2-YL)-METHYLAMINE HYDROCHLORIDE(6628-83-7)
• EPA Substance Registry System: C-(TETRAHYDRO-PYRAN-2-YL)-METHYLAMINE HYDROCHLORIDE(6628-83-7)

Safety Data

• Statements: 41
• Safety Statements: 26-39
• HazardClass: IRRITANT
• Hazardous Substances Data: 6628-83-7(Hazardous Substances Data)

Usage

General Description

C-(Tetrahydro-pyran-2-yl)-methylamine hydrochloride is a chemical compound that consists of a methylamine group attached to a tetrahydro-pyran-2-yl moiety, with a hydrogen chloride salt. It is used in organic synthesis as a reagent for the preparation of various pharmaceutical intermediates, including the production of antihistamines and other therapeutic drugs. C-(TETRAHYDRO-PYRAN-2-YL)-METHYLAMINE HYDROCHLORIDE is also utilized as a building block in the synthesis of complex natural products and other biologically active molecules. Its hydrochloride salt form enhances its solubility and stability, making it a more versatile and useful compound for chemical reactions and drug development.

InChI:InChI=1/C6H13NO/c7-5-6-3-1-2-4-8-6/h6H,1-5,7H2

Upstream product

• 98435-78-0 (+/-)-tetrahydropyran-2-yl-acetic acid amide 
• 111293-46-0 2-(oxan-2-ylmethyl)-2,3-dihydro-1H-isoindole-1,3-dione 
• 181945-29-9 tetrahydropyranmethyl azide 

Downstream Products

• 100-72-1 Tetrahydropyran-2-methanol 
• 93545-84-7 6-hydroxyhexanal lactol 
• 1132671-64-7 (2S,4S,5S,7S)-5-azido-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-8-methyl-nonanoic acid (tetrahydro-pyran-2-ylmethyl)-amide 
• 1160508-19-9 3-tert-butyl-5-((cyclohexylmethyl)((tetrahydro-2H-pyran-2-yl)methyl)amino)-1-methyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one 
• 1442119-79-0 (±)-4-methyl-N-(3,4,5,6-tetrahydro-2H-pyran-2-ylmethyl)-2-[(1-{4-[4-(trifluoromethyl)phenoxy]benzoyl}piperidin-4-yl)methyl]-2H-indazol-5-carboxamide 

Relevant articles and documents

SUBSTITUTED IMIDAZOQUINOLINES, IMIDAZONAPHTHYRIDINES, AND IMIDAZOPYRIDINES, COMPOSITIONS, AND METHODS

Certain 1H-imidazo[4,5-c]quinolines, 6,7,8,9-tetrahydro-1H-imidazo[4,5-c]quinolines, 1H-imidazo[4,5-c][1,5]naphthyridines, 6,7,8,9-tetrahydro-1H-imidazo[4,5-c][1,5]naphthyridines, and 1H-imidazo[4,5-c]pyridines substituted at the 1- and 2-positions, pharmaceutical compositions containing these compounds, methods of making the compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.

CB1 MODULATOR COMPOUNDS

Novel compounds of structural formula (I) are disclosed. As modulators of the Cannabinoid-1 (CB1) receptor, these compounds are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. As such, compounds of the present invention are useful as in the treatment, prevention and suppression of psychosis, memory deficits, cognitive disorders, migraine, neuropathy, neuro-inflammatory disorders (e.g., multiple sclerosis, Guillain-Barre syndrome and the inflammatory sequelae of viral encephalitis), cerebral vascular accidents, head trauma, anxiety disorders, stress, epilepsy, Parkinson's disease, and schizophrenia. The compounds are also useful for the treatment of substance abuse disorders, particularly to opiates, alcohol, and nicotine. The compounds are also useful for the treatment of obesity or eating disorders associated with excessive food intake and complications associated therewith.