66624-43-9 Usage
Structure
A derivative of 1H-indole with a chloroacetyl group and a methyl group
Appearance
Pale yellow solid
Molecular weight
223.68 g/mol
Usage
In the synthesis of various pharmaceuticals and agrochemicals due to its unique structure and reactivity
Biological activities
Potential anti-tumor and antibacterial properties
Research status
Further research needed to fully understand its pharmacological potential and safety profile.
Check Digit Verification of cas no
The CAS Registry Mumber 66624-43-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,6,6,2 and 4 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 66624-43:
(7*6)+(6*6)+(5*6)+(4*2)+(3*4)+(2*4)+(1*3)=139
139 % 10 = 9
So 66624-43-9 is a valid CAS Registry Number.
InChI:InChI=1/C11H12ClNO/c1-8-3-2-4-9-5-6-13(11(8)9)10(14)7-12/h2-4H,5-7H2,1H3
66624-43-9Relevant articles and documents
Indoline and piperazine containing derivatives as a novel class of mixed D2/D4 receptor antagonists. Part 1: Identification and structure-activity relationships
Zhao, He,Thurkauf, Andrew,He, Xiaoshu,Hodgetts, Kevin,Zhang, Xiaoyan,Rachwal, Stanislaw,Kover, Renata X.,Hutchison, Alan,Peterson, John,Kieltyka, Andrzej,Brodbeck, Robbin,Primus, Renee,Wasley, Jan W.F.
, p. 3105 - 3109 (2007/10/03)
Optimization of the lead compound 2-[-4-(4-chloro-benzyl)-piperazin-1-yl]-1-(2,3-dihydro-indol-1-yl)-ethanone 1 by systematic structure-activity relation (SAR) studies lead to two potent compounds 2-[-4-(4-chloro-benzyl)-piperazin-1-yl]-1-(2-methy-2,3-dihydro-indol-1-yl)- ethanone 2n and 2-[-4-(4-chloro-benzyl)-piperazin-1-yl]-1-(2-methy-2,3-dihydro-indol-1-yl)- ethanone 7b. Their related synthesis was also reported.
