66635-89-0

Basic information

• Product Name: 5-(4-chlorobenzoyl)-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrolo-1-carboxylic acid
• Synonyms: 5-(4-chlorobenzoyl)-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrolo-1-carboxylic acid
• CAS NO: 66635-89-0
• Molecular Weight: 289.718
• Mol File: 66635-89-0.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 5-(4-chlorobenzoyl)-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrolo-1-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-chlorobenzoyl)-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrolo-1-carboxylic acid(66635-89-0)
• EPA Substance Registry System: 5-(4-chlorobenzoyl)-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrolo-1-carboxylic acid(66635-89-0)

Safety Data

• Hazardous Substances Data: 66635-89-0(Hazardous Substances Data)

Usage

Molecular structure

Complex structure with a derivative of pyrrolopyrrole and a 4-chlorobenzoyl group

Pharmacological properties

Potential pharmacological properties with potential applications in medicinal chemistry

Subject of interest

Subject of interest for researchers and scientists exploring new drug candidates and therapeutic agents

Potential applications

Could potentially be used in the development of new medications and treatments in the field of medicine

Upstream product

• 66635-81-2 isopropyl 5-p-chlorobenzoyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylate 
• 66635-71-0 i-propyl 1,2-dihydro-3H-pyrrolo<1,2-a>pyrrole-1-carboxylate 
• 14062-80-7 N,N-dimethyl-4-chlorobenzamide 

Relevant articles and documents

Process for preparing 5-aroyl-1,2-dihydro-3H-pyrrolo[1,2-A]pyrrole-1,1-dicarboxylates

5-Aroyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1,1-dicarboxylates of the formula STR1 are prepared from 2-halopyrroles. Hydrolysis and β-decarboxylation of these compounds affords ketorolac and related compounds.

Process for preparing 5-aroyl 1,2-dihydro-3-H pyrrolo[1,2-a]pyrrole-1-carboxylic acids and novel intermediates therein

5-Substituted-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acids of the formula STR1 wherein: X is hydrogen or lower alkyl; Ar is a moiety selected from the group consisting of STR2 in which: Y is oxygen or sulfur; R is hydrogen, methyl, chloro, or bromo, the R substitution being at the 3, 4 or 5 position of the ring; R1 is hydrogen, lower alkyl, lower alkoxyl, lower alkoxycarbonyl, lower alkylcarbonyl, fluoro, chloro or bromo, the R1 substitution being at any available position in the ring; R2 is hydrogen or lower alkyl; are prepared by β-decarboxylation of the corresponding dialkyl-1,1-dicarboxylates. Certain substituted pyrroles are useful as intermediates for preparing the compounds of formula I.

5-Aroyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivatives and process for the production thereof

Novel 5-aroyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid compounds represented by the formula STR1 and the pharmaceutically acceptable, non-toxic esters and salts thereof, wherein R is hydrogen or a lower alkyl group containing from 1 to 4 car