66638-22-0 Usage
Description
O-ACETYL-L-SERINE HYDROCHLORIDE is a chemical compound that serves as a cysteine precursor, playing a crucial role in the biosynthesis of cysteine. It is an essential component in various biological processes and has potential applications in different industries.
Uses
Used in Biochemical Research:
O-ACETYL-L-SERINE HYDROCHLORIDE is used as a substrate for the identification, differentiation, and characterization of O-acetyl-L-serine(thiol)lyase(s) (OASTL) enzymes, which are involved in the biosynthesis of cysteine. This application is crucial for understanding the mechanisms of cysteine production and its role in various biological processes.
Used in Pharmaceutical Industry:
O-ACETYL-L-SERINE HYDROCHLORIDE can be used as an intermediate in the synthesis of pharmaceutical compounds, particularly those targeting the regulation of cysteine levels in the body. Its role as a cysteine precursor makes it a valuable component in the development of drugs that address conditions related to cysteine metabolism.
Used in Nutritional Supplements:
O-ACETYL-L-SERINE HYDROCHLORIDE may be utilized in the development of nutritional supplements designed to support optimal cysteine levels and overall health. As a precursor to cysteine, it can contribute to the maintenance of proper cellular function and the synthesis of essential molecules such as glutathione, which plays a vital role in detoxification and immune system support.
Biochem/physiol Actions
O-Acetyl-L-serine, a cysteine precursor, is used as a substrate for the identification, differentiation and characterization of O-acetyl-L-serine(thiol)lyase(s) (OASTL) involved in cysteine biosynthesis.
Check Digit Verification of cas no
The CAS Registry Mumber 66638-22-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,6,6,3 and 8 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 66638-22:
(7*6)+(6*6)+(5*6)+(4*3)+(3*8)+(2*2)+(1*2)=150
150 % 10 = 0
So 66638-22-0 is a valid CAS Registry Number.
InChI:InChI=1/C5H9NO4.ClH/c1-3(7)10-2-4(6)5(8)9;/h4H,2,6H2,1H3,(H,8,9);1H
66638-22-0Relevant articles and documents
Switching Lysophosphatidylserine G Protein-Coupled Receptor Agonists to Antagonists by Acylation of the Hydrophilic Serine Amine
Sayama, Misa,Uwamizu, Akiharu,Ikubo, Masaya,Chen, Luying,Yan, Ge,Otani, Yuko,Inoue, Asuka,Aoki, Junken,Ohwada, Tomohiko
, p. 10059 - 10101 (2021/07/28)
Three human G protein-coupled receptors (GPCRs)—GPR34/LPS1, P2Y10/LPS2, and GPR174/LPS3—are activated specifically by lysophosphatidylserine (LysoPS), an endogenous hydrolysis product of a cell membrane component, phosphatidylserine (PS). LysoPS consists of-serine, glycerol, and fatty acid moieties connected by phosphodiester and ester linkages. We previously generated potent and selective GPCR agonists by modification of the three modules and the ester linkage. Here, we show that a novel modification of the hydrophilic serine moiety, that is, N-acylations of the serine amine, converted a GPR174 agonist to potent GPR174 antagonists. Structural exploration of the amide functionality provided access to a range of activities from agonist to partial agonist to antagonist. The present study would provide a new strategy for the development of lysophospholipid receptor antagonists.
An efficient synthesis of N-methyl amino acids by way of intermediate 5-oxazolidinones
Aurelio, Luigi,Box, John S.,Brownlee, Robert T. C.,Hughes, Andrew B.,Sleebs, Marianne M.
, p. 2652 - 2667 (2007/10/03)
N-Methyl amino acids occur in many natural products. Experimental strategies are presented for a unified approach to the synthesis of N-methyl derivatives through 5-oxazolidinones of the 20 common L-amino acids. The amino acids with reactive side chains that required protecting groups or devoted syntheses for side chain construction for N-methylation to proceed included serine, threonine, tyrosine, cysteine, methionine, tryptophan, asparagine, histidine, and arginine. The studies have provided improved methods for the preparation of N-methyl serine, threonine, and tyrosine. All 20 of the common L-amino acids are now available in suitable forms for solid or solution-phase peptide synthesis.