66659-90-3

Basic information

• Product Name: 1,2-bis[4-(trifluoromethyl)phenyl]ethanone
• Synonyms: 1,2-bis[4-(trifluoromethyl)phenyl]ethanone
• CAS NO: 66659-90-3
• Molecular Weight: 332.245
• Mol File: 66659-90-3.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 1,2-bis[4-(trifluoromethyl)phenyl]ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-bis[4-(trifluoromethyl)phenyl]ethanone(66659-90-3)
• EPA Substance Registry System: 1,2-bis[4-(trifluoromethyl)phenyl]ethanone(66659-90-3)

Safety Data

• Hazardous Substances Data: 66659-90-3(Hazardous Substances Data)

Upstream product

• 108-94-1 cyclohexanone 
• 103411-25-2 4-(trifluoromethyl)(trimethylsilyl)methanone 
• 25753-16-6 4-(trifluoromethyl)benzoic anhydride 
• 329-15-7 4-trifluoromethyl-phenyl acetyl chloride 
• 1002717-44-3 1,2-bis(p-trifluoromethylphenyl)ethylene 

Downstream Products

• 73790-20-2 4,4'-bis(trifluoromethyl)benzil 
• 455-24-3 4-trifluoromethylbenzoic acid 

Relevant articles and documents

A structureeactivity relationship study on the Wacker oxidation of stilbenes at ambient condition

To evaluate which structural elements of the stilbenes are responsible for their activity on the Wacker oxidation, a series of stilbenes with various functional moieties and substitution patterns were considered. In this regard, it is found that the oxidation rate of stilbenes strongly depends on their structures to give the corresponding carbonyl compounds. Consequently, the ortho position of alkene and methoxy groups plays a key role in the complexation with PdCl2. The oxidation process is clean with high selectivity of product and low percentage of byproducts.

Vanilloid receptor ligands and their use in treatments

Therapeutic benzimidazoles and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.

TiCl4-Zn induced reductive acylation of ketones with acylsilanes

Acylsilanes were found to react with ketones in the presence of a low-valent titanium reagent generated from titanium(IV) chloride and zinc, giving the corresponding reductive acylated compounds.