66662-48-4

Basic information

• Product Name: 2-Chloro-4,6-dimethyl-3-pyridinecarboxylic acid
• Synonyms: 2-CHLORO-4,6-DIMETHYL-3-PYRIDINECARBOXYLIC ACID;2-chloro-4,6-dimethylpyridine-3-carboxylic acid
• CAS NO: 66662-48-4
• Molecular Formula: C8H8ClNO2
• Molecular Weight: 185.61
• Product Categories: Heterocycle
• Mol File: 66662-48-4.mol
• Article Data: 3

Chemical Properties

• Melting Point: 139-140 °C(Solv: ethyl acetate (141-78-6))
• Boiling Point: 342.3 °C at 760 mmHg
• Flash Point: 160.8 °C
• Appearance: /
• Density: 1.328 g/cm³
• Vapor Pressure: 2.91E-05mmHg at 25°C
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 2.11±0.38(Predicted)
• CAS DataBase Reference: 2-Chloro-4,6-dimethyl-3-pyridinecarboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-4,6-dimethyl-3-pyridinecarboxylic acid(66662-48-4)
• EPA Substance Registry System: 2-Chloro-4,6-dimethyl-3-pyridinecarboxylic acid(66662-48-4)

Safety Data

• Hazardous Substances Data: 66662-48-4(Hazardous Substances Data)

Usage

General Description

2-Chloro-4,6-dimethyl-3-pyridinecarboxylic acid, also known as Chloropyridine, is a chemical compound with the molecular formula C8H8ClNO2. It is a chlorinated derivative of pyridinecarboxylic acid and contains a carboxylic acid functional group. 2-Chloro-4,6-dimethyl-3-pyridinecarboxylic acid is often used in the synthesis of pharmaceuticals and agrochemicals due to its potential as an intermediate in organic synthesis. It is also known for its antimicrobial and antifungal properties, making it useful in the production of pesticides and antifungal agents. Additionally, 2-Chloro-4,6-dimethyl-3-pyridinecarboxylic acid is utilized in the manufacturing of dyes, pigments, and other fine chemicals. However, it is important to handle this compound with care due to its potential hazards to human health and the environment.

InChI:InChI=1/C8H8ClNO2/c1-4-3-5(2)10-7(9)6(4)8(11)12/h3H,1-2H3,(H,11,12)/p-1

Upstream product

• 140413-44-1 2-chloro-4,6-dimethylnicotinic acid amide 
• 14237-71-9 2-chloro-4,6-dimethylnicotinonitrile 
• 769-28-8 3-Cyano-4,6-dimethyl-2(1H)-pyridon 

Downstream Products

• 132707-73-4 2,4,6,8,11-Pentamethyl-6,11-dihydro-benzo[b]pyrido[2,3-e][1,4]diazepin-5-one 
• 339151-88-1 methyl 2-chloro-4,6-dimethylnicotinate 

Relevant articles and documents

Synthesis of some halogen- and nitro-substituted nicotinic acids and their fragmentation under electron impact

Features of electrophilic and nucleophilic substitution under chlorination and nitration reactions conditions have been investigated for 6-hydroxy- and 6-methyl-substituted derivatives of 3-cyano-4-methyl-2(1H)-pyridones. The polychloro- and nitro-substituted 3-cyano-4-methylpyridines obtained were used as synthons in the synthesis of some polyhalo- and nitro-substituted nicotinic acids and their amides. The fragmentation pathways of the synthesized compounds under electron impact have been studied.

2-Methyl-6-alkyl-11-aminoalkyl-6,11-dihydro-5H-pyrido(2,3-B)(1,5)benzodiazepin-5-ones and salts thereof

Compounds of the formula STR1 wherein R1 --is hydrogen, alkyl of 1 to 6 carbon atoms or benzyl; R2 --is alkyl of 1 to 6 carbon atoms, cycloalkyl of 5 to 7 carbon atoms or, together with R1 and the adjacent nitrogen atom, pyrrolidino, piperidino, hexamethyleneimino, morpholino or N'-methyl-piperazino, where each of the heterocycles may have one or two alkyl of 1 to 3 carbon atoms or one or two methoxy substituents attached thereto; R3,--r4 and R5 are each hydrogen or methyl; R6 --is alkyl of 1 to 4 carbon atoms; and A--is alkylene of 2 to 4 carbon atoms; And non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as their salts are useful as bronchospasmolytics and bronchosecretolytics.