666714-63-2Relevant articles and documents
Hexafluoroisopropanol as solvent and promotor in the Paal-Knorr synthesis of N-substituted diaryl pyrroles
Schirmacher, Robert H.E.,R?sch, Daniel,Thomas, Franziska
, (2021/02/20)
An additive-free synthesis of challenging N-substituted aryl pyrroles from the often poorly soluble corresponding 1,4-diketones by means of the Paal-Knorr pyrrole synthesis is reported, which makes use of the unique properties of 1,1,1,3,3,3-hexafluoroisopropanol (HFIP) as a solvent and reaction promotor. Our procedure offers simple execution and purification as well as easy scale-up and can be applied in the Paal-Knorr synthesis of a large number of structurally diverse pyrroles including the synthetically challenging tetra- and penta-substituted pyrroles in moderate to excellent yields. HFIP can also be used as solvent in the Paal-Knorr synthesis of furans and thiophenes; however, the solvent effect is more pronounced in synthesis of pyrroles.
An efficient synthesis of N3,4-diphenyl-5-(4-fluorophenyl)-2-isopropyl-1H- 3-pyrrolecarboxamide, a key intermediate for atorvastatin synthesis
Pandey, Pramod S.,Rao, T. Srinivasa
, p. 129 - 131 (2007/10/03)
An efficient synthesis of N3,4-diphenyl-5-(4-fluorophenyl)-2-isopropyl-1H- 3-pyrrolecarboxamide, a key intermediate for the synthesis of an effective HMG-CoA reductase inhibitor atorvastatin, is described. The synthesis is based on the 1,3-dipolar cycload
