66684-61-5

Basic information

• Product Name: 1,5-DIFLUORO-3-METHOXY-2-NITRO-BENZENE
• Synonyms: 1,5-DIFLUORO-3-METHOXY-2-NITRO-BENZENE;2,4-Difluoro-6-methoxynitrobenzene;1,5-Difluoro-3-Methoxy-2-nitro-benz;Benzene, 1,5-difluoro-3-Methoxy-2-nitro-;1,5-Difluoro-3-methoxy-2-nitrobenzene, 3,5-Difluoro-2-nitrophenyl methyl ether;3,5-Difluoro-2-nitroanisole【1,5-Difluoro-3-methoxy-2-nitrobenzene】
• CAS NO: 66684-61-5
• Molecular Formula: C₇H₅F₂NO₃
• Molecular Weight: 189.117
• EINECS: 200-258-5
• Mol File: 66684-61-5.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 238℃
• Flash Point: 98℃
• Appearance: /
• Density: 1.414
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1,5-DIFLUORO-3-METHOXY-2-NITRO-BENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,5-DIFLUORO-3-METHOXY-2-NITRO-BENZENE(66684-61-5)
• EPA Substance Registry System: 1,5-DIFLUORO-3-METHOXY-2-NITRO-BENZENE(66684-61-5)

Safety Data

• Hazardous Substances Data: 66684-61-5(Hazardous Substances Data)

Usage

General Description

1,5-Difluoro-3-methoxy-2-nitro-benzene is a chemical compound with the molecular formula C7H5F2NO3. It is a pale yellow crystalline solid, commonly used as an intermediate in the synthesis of various organic compounds. This chemical is known for its ability to inhibit the growth of various microorganisms, making it useful in the production of antiseptics and disinfectants. It is also used as a precursor in the synthesis of pharmaceuticals and agrochemicals. Additionally, 1,5-difluoro-3-methoxy-2-nitro-benzene is used in the production of dyes and polymers. However, it is important to handle this chemical with caution, as it is toxic and may cause irritation to the skin, eyes, and respiratory system upon exposure.

Upstream product

• 315-14-0 1,3,5-trifluoro-2-nitrobenzene 
• 124-41-4 sodium methylate 
• 372-38-3 1,3,5-trifluorobenzene 
• 151414-46-9 3,5-Difluoro-2-nitrophenol 
• 74-88-4 methyl iodide 
• 93343-10-3 3,5-difluoroanisol 
• 2713-34-0 3,5-difluorophenol 
• 67-56-1 methanol 

Downstream Products

• 862270-96-0 N-(2,4-dimethoxybenzyl)-5-fluoro-3-methoxy-2-nitrobenzenamine 
• 256454-00-9 5-fluoro-3-methoxy-2-nitrophenol 
• 1159795-35-3 2-bromo-1-(5-fluoro-3-methoxy-2-nitrophenyl)-4-methyl-1H-imidazole 
• 1226805-66-8 1-(5-fluoro-3-methoxy-2-nitrophenyl)-4-methyl-1H-imidazole 
• 1159795-36-4 4-(1-(5-fluoro-3-methoxy-2-nitrophenyl)-4-methyl-1H-imidazol-2-yl)-3-methylpyridine 
• 1159795-37-5 N-(4-fluoro-2-methoxy-6-(4-methyl-2-(3-methylpyridin-4-yl)-1H-imidazol-1-yl)phenyl)acetamide 
• 1226803-99-1 8-fluoro-6-methoxy-1-(2-methoxyphenyl)-3-methylimidazo[5,1-c][1,2,4]benzotriazine 
• 1226803-97-9 8-fluoro-6-methoxy-1-(3-methoxyphenyl)-3-methylimidazo[5,1-c][1,2,4]benzotriazine 

Relevant articles and documents

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The invention relates to an amino pyrimidine compound and a preparation method and application thereof. The amino pyrimidine compound has a structure as shown in a formula I. The formula is shown in the description. The compound is an inhibitor of an epidermal growth factor receptor (EGFR) kinase. The invention further relates to a medicine composition comprising the compound, a preparation methodand application thereof in preparation of anti-tumor medicines.

5 OXO-5,8-DIHYDROPYRIDO[2,3-d]PYRIMIDINE DERIVATIVES AS CAMKII KINASE INHIBITORS FOR TREATING CARDIOVASCULAR DISEASES

The present invention relates to 5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine derivatives, to their preparation and to their therapeutic use.

Highly potent, selective, and orally active phosphodiesterase 10A inhibitors

The identification of highly potent and orally active phenylpyrazines for the inhibition of PDE10A is reported. The new analogues exhibit subnanomolar potency for PDE10A, demonstrate high selectivity against all other members of the PDE family, and show desired druglike properties. Employing structure-based drug design approaches, we methodically explored two key regions of the binding pocket of the PDE10A enzyme to alter the planarity of the parent compound 1 and optimize its affinity for PDE10A. Bulky substituents at the C9 position led to elimination of the mutagenicity of 1, while a crucial hydrogen bond interaction with Glu716 markedly enhanced its potency and selectivity. A systematic assessment of the ADME and PK properties of the new analogues led to druglike development candidates. One of the more potent compounds, 96, displayed an IC50 for PDE10A of 0.7 nM and was active in predictive antipsychotic animal models.