670-83-7Relevant articles and documents
Structure-activity relationship studies on 2-heteroaryl-4-arylimidazoles NPY5 receptor antagonists
Elliott, Richard L.,Oliver, Robert M.,LaFlamme, Janet A.,Gillaspy, Melissa L.,Hammond, Marlys,Hank, Richard F.,Maurer, Tristan S.,Baker, Demetria L.,DaSilva-Jardine, Paul A.,Stevenson, Ralph W.,Mack, Christine M.,Cassella, James V.
, p. 3593 - 3596 (2003)
A series of 2-heteroaryl-4-arylimidazoles with potent in vitro activity at the NPY5 receptor was developed. Introduction of electron-withdrawing groups on the 4-aryl ring led to a significant improvement of in vitro potency. Several analogues from this series had anorectic activity in rodent feeding models, but were also found to have undesired behavioral effects in spontaneous locomotor activity.
Structure and Reactivity of Highly Twisted N-Acylimidazoles
Stone, Elizabeth A.,Mercado, Brandon Q.,Miller, Scott J.
supporting information, p. 2346 - 2351 (2019/04/10)
A modular and efficient synthesis of highly twisted N-acylimidazoles is reported. These twist amides were characterized via X-ray crystallography, NMR spectroscopy, IR spectroscopy, and DFT calculations. Modification of the substituent proximal to the amide revealed a maximum torsional angle of 88.6° in the solid state, which may be the most twisted amide reported for a nonbicyclic system to date. Reactivity and stability studies indicate that these twisted N-acylimidazoles may be valuable, namely as acyl transfer reagents.
ZnCl2-Catalyzed [3 + 2] Cycloaddition of Benzimidates and 2 H-Azirines for the Synthesis of Imidazoles
Shi, Shoujie,Xu, Kang,Jiang, Cheng,Ding, Zhenhua
, p. 14791 - 14796 (2018/11/23)
ZnCl2-catalyzed [3 + 2] cycloaddition reaction of benzimidates and 2H-azirines has been developed. This convenient method allowed the efficient construction of a series of multisubstituted imidazoles in moderate to good yields under mild reaction conditions. This transformation exhibits good reactivity and high functional group tolerance.