67169-91-9

Basic information

• Product Name: N-(2-amino-4-ethoxyphenyl)acetamide
• Synonyms: N-(2-amino-4-ethoxyphenyl)acetamide;acetamide, N-(2-amino-4-ethoxyphenyl)-;N-(2-amino-4-ethoxyphenyl)acetamide(SALTDATA: FREE);N-(2-amino-4-ethoxy-phenyl)ethanamide
• CAS NO: 67169-91-9
• Molecular Formula: C₁₀H₁₄N₂O₂
• Molecular Weight: 194.23036
• EINECS: 266-594-0
• Mol File: 67169-91-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 409°C at 760 mmHg
• Flash Point: 201.2°C
• Appearance: /
• Density: 1.174g/cm³
• Vapor Pressure: 6.71E-07mmHg at 25°C
• Refractive Index: 1.593
• CAS DataBase Reference: N-(2-amino-4-ethoxyphenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-amino-4-ethoxyphenyl)acetamide(67169-91-9)
• EPA Substance Registry System: N-(2-amino-4-ethoxyphenyl)acetamide(67169-91-9)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 67169-91-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H14N2O2/c1-3-14-8-4-5-10(9(11)6-8)12-7(2)13/h4-6H,3,11H2,1-2H3,(H,12,13)

Upstream product

• 885-81-4 N-(4-ethoxy-2-nitrophenyl)acetamide 
• 62-44-2 4-ethoxyacetanilide 

Downstream Products

• 118933-94-1 1-acetyl-5-ethoxybenzotriazole 
• 1197-37-1 4-ethoxy-benzene-1,2-diamine 
• 423734-50-3 5-ethoxy-2-benzyl-1⁽³⁾H-benzimidazole 
• 5895-31-8 5-ethoxy-2-methyl-1(3)H-benzoimidazole 
• 132841-41-9 N-[4-Ethoxy-2-(3-phenyl-thioureido)-phenyl]-acetamide 
• 132841-45-3 N-[2-(3-Allyl-thioureido)-4-ethoxy-phenyl]-acetamide 
• 131336-23-7 2-benzyl-5⁽⁶⁾-hydroxybenzimidazole 
• 50591-21-4 5-ethoxybenzimidazole 
• 55489-15-1 6-ethoxy-2-mercaptobenzimidazole 

Relevant articles and documents

Synthesis of N-acetyl derivatives of 5- and 6-ethoxy-2-methylthiobenzimidazole and their cardiotonic activity

The regioselectivity of the N-acetylation of 5- and 6-ethoxy-2-methylthiobenzimidazole for various acetylating agents under various conditions has been investigated. The cardiotonic activity of the 1-acetyl-5-ethoxy- and 1-acetyl-6-ethoxy-2-methylthiobenzimidazoles synthesized and of their 5,6-diethoxy analog has been studied. 1997 Plenum Publishing Corporation.

Inhibition of Rat Hepatic Microsomal Aminopyrine N-Demethylase Activity by Benzimidazole Derivatives. Quantitative Structure-Activity Relationships

Eighty-two benzimidazole derivatives have been prepared and tested for the ability to inhibit cytochrome P-450 mediated enzyme activity (aminopyrine N-demethylase) from phenobarbitone-induced rat hepatic microsomes.Using physicochemical parameters and multiple regression analysis, we derived a quantitative structure-activity relationship (QSAR) that describes up to 87percent of the data variance in terms of hydrophobic and electronic effects and the molar refractivity of the substituent in the 2-position of the benzimidazole ring.