671775-95-4Relevant articles and documents
Freezing the Bioactive Conformation to Boost Potency: The Identification of BAY85-8501, a Selective and Potent Inhibitor of Human Neutrophil Elastase for Pulmonary Diseases
Vonnussbaum, Franz,Li, Volkhart M.-J.,Allerheiligen, Swen,Anlauf, Sonja,B?rfacker, Lars,Bechem, Martin,Delbeck, Martina,Fitzgerald, Mary F.,Gerisch, Michael,Gielen-Haertwig, Heike,Haning, Helmut,Karthaus, Dagmar,Lang, Dieter,Lustig, Klemens,Meibom, Daniel,Mittendorf, Joachim,Rosentreter, Ulrich,Sch?fer, Martina,Sch?fer, Stefan,Schamberger, Jens,Telan, Leila A.,Tersteegen, Adrian
, p. 1163 - 1173 (2015/07/07)
Human neutrophil elastase (HNE) is a key protease for matrix degradation. High HNE activity is observed in inflammatory diseases. Accordingly, HNE is a potential target for the treatment of pulmonary diseases such as chronic obstructive pulmonary disease
MULTIMERS OF HETEROCYCLIC COMPOUNDS AND THEIR USE
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Page/Page column 49, (2008/06/13)
A compound of formula (I): M-L-M, wherein L is a linker and each M is independently a group of formula (II): is useful in therapy, e.g. of respiratory diseases.
1,4-DIARYL-DIHYDROPYRIMIDIN-2-ONES AND THEIR USE AS HUMAN NEUTROPHIL ELASTASE INHIBITORS
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Page/Page column 39, (2010/02/13)
The invention relates to novel heterocyclic derivatives of the general formula (I), processes for their preparation, and their use in medicaments, especially for the treatment of chronic obstructive pulmonary diseases, acute coronary syndrome, acute myoca