672-78-6

Basic information

• Product Name: METHYL P-TOLUENESULFINATE
• Synonyms: METHYL P-TOLUENESULFINATE;MGPLBSPZSIFUQX-UHFFFAOYSA-N
• CAS NO: 672-78-6
• Molecular Formula: C₈H₁₀O₂S
• Molecular Weight: 170.23
• Mol File: 672-78-6.mol
• Article Data: 75

Chemical Properties

• Boiling Point: 86-88 °C(Press: 4 Torr)
• Appearance: /
• Density: 1.22±0.1 g/cm3(Predicted)
• CAS DataBase Reference: METHYL P-TOLUENESULFINATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL P-TOLUENESULFINATE(672-78-6)
• EPA Substance Registry System: METHYL P-TOLUENESULFINATE(672-78-6)

Safety Data

• Hazardous Substances Data: 672-78-6(Hazardous Substances Data)

Usage

Uses

p-Toluenesulfinic Acid Methyl Ester is an intermediate in the synthesis of Sulfonamides.

Upstream product

• 186581-53-3 diazomethane 
• 536-57-2 p-toluene sulfinic acid 
• 67-56-1 methanol 
• 10439-23-3 4-methylbenzenesulfinyl chloride 
• 4973-66-4 methyl thiotosylate 
• 68819-94-3 p-tolyl benzeneselenosulfonate 
• 25566-59-0 N-methyl-N-(2-phenethyl)-4-methylbenzenesulfonamide 
• 72818-30-5 Anisoyl-4-tolylsulfon 
• 128792-61-0 (bromo)(ethoxy) methyl 4-methylphenylsulfone 
• 112897-65-1 2-Thiabicyclo<2.2.1>heptan-6-on-2,2-dioxid-p-tolylsulfonylhydrazon 
• 15210-25-0 bicyclo[10.3.0]pentadec-1⁽¹²⁾-en-13-one 
• 1950-78-3 p-toluenesulfonyl iodide 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 18137-96-7 nitromethane anion 

Downstream Products

• 10439-23-3 4-methylbenzenesulfinyl chloride 
• 17530-89-1 p-tolyl phenacyl sulphoxide 
• 67-56-1 methanol 
• 6873-93-4 1-[(4-methylphenyl)sulfinyl]piperidine 
• 16066-33-4 4-<(4-methylphenyl)sulfinyl>morpholine 
• 114376-01-1 propyl 4-methylbenzenesulfinate 
• 116471-84-2 4-Methyl-benzenesulfinic acid (S)-allyl-methyl-amide 
• 130877-76-8 methyl 2,4-dimethoxy-6-(p-tolylsulfinyl) methyl benzoate 
• 134876-51-0 t-butylsulfonyl p-tolylsulfinyl methane 
• 86783-14-4 N,N-Dimethyl-N'-[2-(toluene-4-sulfinyl)-eth-(E)-ylidene]-hydrazine 
• 104871-67-2 (R)-2-(p-tolylsulfinyl)-1-cyclohexanone 
• 104871-69-4 2-((S)-Toluene-4-sulfinyl)-cyclohexanone 
• 82483-97-4 Phenyl-[1-phenyl-2-(toluene-4-sulfinyl)-eth-(Z)-ylidene]-amine 
• 129083-18-7 (+/-)-(phenylsulfonyl)(p-tolylsulfinyl)methane 

Relevant articles and documents

NaHSO3-Mediated Direct Synthesis of Sulfinic Esters from Sulfonyl Hydrazides under Transition-Metal-Free Conditions

We have developed a protocol for the NaHSO3-promoted esterification of sulfonyl hydrazides with alcohols for the synthesis of sulfinic esters. Various sulfonyl hydrazides could be converted to the corresponding sulfinic esters in good to high yields. The merits of this protocol include mild transition-metal-free reaction conditions, an inexpensive and available reagent, and operational simplicity. Controlled experiments reveal that this transformation probably undergoes via a radical pathway. (Figure presented.).

Direct synthesis of sulfinic esters via ultrasound accelerated tandem reaction of thiols and alcohols with N-bromosuccinimide

The direct transformation of various thiols and simple alcohols with N-bromosuccinimide into sulfinic esters has been investigated by using different categories of base/acidic catalysts as well as co-solvents under varied reaction conditions. The reaction was found out to afford the sulfinic esters with high yields in the absence of catalysts, especially within the shorter time under the acceleration of ultrasonic irradiation than under the longer-lasting conventional stirring conditions.

Isocyanide-Induced Esterification of Sulfinic Acids to Access Sulfinates

The isocyanide-induced esterification of sulfinic acids with alcohols or thiophenols access to sulfinates has been developed. Various primary, secondary, and tertiary alcohols could be compatible with the established protocols. Notably, such an isocyanide-induced synthetic strategy presented the advantages of simple operation, good functional group tolerance, and more than 40 examples up to 99% yields. (Figure presented.).