67252-79-3

Basic information

• Product Name: (-)(S)-3-Methyl-1-phenyl-2-butanol
• Synonyms: (-)(S)-3-Methyl-1-phenyl-2-butanol
• CAS NO: 67252-79-3
• Molecular Weight: 164.247
• Mol File: 67252-79-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (-)(S)-3-Methyl-1-phenyl-2-butanol(CAS DataBase Reference)
• NIST Chemistry Reference: (-)(S)-3-Methyl-1-phenyl-2-butanol(67252-79-3)
• EPA Substance Registry System: (-)(S)-3-Methyl-1-phenyl-2-butanol(67252-79-3)

Safety Data

• Hazardous Substances Data: 67252-79-3(Hazardous Substances Data)

Upstream product

• 196106-01-1 (R)-3-methyl-2-phenylbutan-1-amine 
• 67152-34-5 (R)-3-Methyl-2-phenylbutyltosylat 
• 46114-16-3 2-amino-1-phenyl-3-methylbutane 
• 86527-09-5 Acetic acid 1-benzyl-2-methyl-propyl ester 
• 74669-79-7 (S)-3-Methyl-1-phenyl-3-buten-2-ol 
• 705-58-8 3-methyl-1-phenyl-2-butanol 
• 464-78-8 (1S)-(+)-ketopinic acid 
• 74669-78-6 2-(α-Benzyl-β-hydroxy-β-methylpropyloxy)tetrahydropyran 
• 17763-67-6 Phenyl triflate 
• 1888-75-1 isopropyllithium 

Relevant articles and documents

Microbially Mediated Enantioselective Ester Hydrolyses Utilizing Rhizopus nigricans. A New Method of Assigning the Absolute Stereochemistry of Acyclic 1-Arylalkanols

The fungus Rhizopus nigricans has been used to effect the enantioselective hydrolysis of 22 acetates of acyclic 1-arylalkanols.The absolute stereochemistry of all the chiral alcohols formed can be accounted for by a rule which is based on the relative sizes of substituents on the carbinol carbon.The relative sizes of substituents deduced from these hydrolyses have been compared with those assigned from Horeau's method for the same compounds and found to be identical; i.e., a phenyl group or heterocyclic ring is always larger than an alkyl group.The use of R. nigricans to prepare chiral alcohols and use of the rule to predict their configuration constitute a new method of assigning the absolute stereochemistry of secondary alcohols.With minor modifications this method can also be used to prepare gram quantities of chiral alcohols of both configurations.

Chiral Mitsunobu reactions with (1S)-(+)-ketopinic acid: Kinetic resolutions of secondary alcohols

Several secondary alcohols undergo the Mitsunobu reaction with triphenylphosphine, diethyl azodicarboxylate and (1S)-(+)-ketopinic acid (0.5 equiv. each relative to alcohol) in CH2Cl2 solution at -23°C, to furnish the chiral secondar