67256-21-7

Basic information

• Product Name: Hepatocyte Growth Factor
• Synonyms: Hepatopoietin a;Lymphokines and cytokines, scatter factor;Scatter factor;Anti-DFNB39;Anti-F-TCF;Anti-hepatocyte growth factor (hepapoietin A;Anti-HGF antibody produced in rabbit;Anti-HGFB
• CAS NO: 67256-21-7
• Molecular Weight: 0
• Mol File: 67256-21-7.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Storage Temp.: -20°C
• CAS DataBase Reference: Hepatocyte Growth Factor(CAS DataBase Reference)
• NIST Chemistry Reference: Hepatocyte Growth Factor(67256-21-7)
• EPA Substance Registry System: Hepatocyte Growth Factor(67256-21-7)

Safety Data

• Hazardous Substances Data: 67256-21-7(Hazardous Substances Data)

Usage

Description

Hepatocyte growth factor (HGF) is a multifunctional growth factor that plays a crucial role in various biological processes, including cell growth, proliferation, and morphogenesis. It is a heterodimer, non-glycosylated polypeptide chain consisting of an α-chain of 463 amino acids and a β-chain of 234, with a total molecular mass of 80.017 kDa. The gene encoding this protein is localized on human chromosome 7q21.1.

Uses

Used in Pharmaceutical Industry:
Hepatocyte growth factor is used as a therapeutic agent for promoting liver regeneration and repair, as well as treating various liver diseases, such as cirrhosis and hepatitis. It stimulates the proliferation and differentiation of hepatocytes, which helps in the regeneration of liver tissue and the restoration of liver function.
Used in Regenerative Medicine:
HGF is used as a regenerative medicine tool for promoting tissue repair and regeneration in various organs, including the liver, kidney, and heart. Its ability to stimulate cell growth, proliferation, and morphogenesis makes it a promising candidate for treating tissue damage and promoting the healing process.
Used in Cancer Research:
Hepatocyte growth factor is used as a research tool in cancer biology to study its role in tumor growth, invasion, and metastasis. It has been implicated in the regulation of various signaling pathways involved in cancer progression, making it an important target for developing novel cancer therapies.
Used in Wound Healing:
HGF is used as a wound healing agent to promote the healing process in various types of injuries, including burns, cuts, and surgical wounds. Its ability to stimulate cell migration, proliferation, and tissue repair makes it a valuable component in wound healing therapies.
Used in Cosmetic Industry:
Hepatocyte growth factor is used as an anti-aging ingredient in cosmetic products, such as creams and serums, to promote skin regeneration and improve skin texture. Its ability to stimulate cell growth and proliferation can help reduce the appearance of fine lines, wrinkles, and other signs of aging.

Biochem/physiol Actions

Hepatocyte growth factor (HGF) regulates both cell growth and cell motility. It exerts a strong mitogenic effect on hepatocytes and primary epithelial cells. HGF synergizes with interleukin-3 and granulocyte-macrophage colony-stimulating factor (GM-CSF) to stimulate colony formation of hematopoietic progenitor cells in vitro and may, therefore, also modulate hematopoiesis. It is expressed in brain tumors.