67287-53-0

Basic information

• Product Name: 6-Chloro-2,3,4,5-tetrahydro-7,8-dimethoxy-1-(4-methoxyphenyl)-1H-3-benzazepine
• Synonyms: 1H-3-BENZAZEPINE, 6-CHLORO-2,3,4,5-TETRAHYDRO-7,8-DIMETHOXY-1-(4-METHOXYPHENYL)-;6-Chloro-7,8-dimethoxy-1-(4-methoxyphenyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine;6-chloro-7,8-diMethoxy-1-(4-Methoxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine;INTERMEDIATE OF FENOLDOPAM;6-Chloro-2,3,4,5-tetrahydro-7,8-dimethoxy-1-(4-methoxyphenyl)-1H-3-benzazepine
• CAS NO: 67287-53-0
• Molecular Formula: C₁₉H₂₂ClNO₃
• Molecular Weight: 347.84
• EINECS: 266-633-1
• Mol File: 67287-53-0.mol
• Article Data: 5

Chemical Properties

• Melting Point: 140-145°C
• Boiling Point: 479.2 °C at 760 mmHg
• Flash Point: 243.6 °C
• Appearance: /
• Density: 1.166 g/cm³
• Vapor Pressure: 2.42E-09mmHg at 25°C
• Refractive Index: 1.555
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 9.16±0.40(Predicted)
• CAS DataBase Reference: 6-Chloro-2,3,4,5-tetrahydro-7,8-dimethoxy-1-(4-methoxyphenyl)-1H-3-benzazepine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Chloro-2,3,4,5-tetrahydro-7,8-dimethoxy-1-(4-methoxyphenyl)-1H-3-benzazepine(67287-53-0)
• EPA Substance Registry System: 6-Chloro-2,3,4,5-tetrahydro-7,8-dimethoxy-1-(4-methoxyphenyl)-1H-3-benzazepine(67287-53-0)

Safety Data

• Hazardous Substances Data: 67287-53-0(Hazardous Substances Data)

Usage

General Description

6-Chloro-2,3,4,5-tetrahydro-7,8-dimethoxy-1-(4-methoxyphenyl)-1H-3-benzazepine is a chemical compound that belongs to the class of benzazepines. It contains a chloro group and two methoxy groups, as well as a 4-methoxyphenyl substituent. 6-Chloro-2,3,4,5-tetrahydro-7,8-dimethoxy-1-(4-methoxyphenyl)-1H-3-benzazepine has potential pharmacological activity and may be used in the development of drugs for various medical purposes. Its specific properties and uses would depend on further research and testing.

InChI:InChI=1/C19H22ClNO3/c1-22-13-6-4-12(5-7-13)16-11-21-9-8-14-15(16)10-17(23-2)19(24-3)18(14)20/h4-7,10,16,21H,8-9,11H2,1-3H3

Upstream product

• 71636-38-9 N-[2-hydroxy-2-(4'-methoxyphenyl)ethyl]-2-(2-chloro-3,4-dimethoxyphenyl)ethylamine 
• 621-59-0 isovanillin 
• 637-69-4 4-Methoxystyrene 
• 93983-14-3 2-chloro-3,4-dimethoxybenzyl chloride 
• 5417-17-4 2-chloro-3,4-dimethoxybenzaldehyde 
• 19484-05-0 1-((4-methoxy)phenyl)-1,2-dibromoethane 
• 37687-57-3 2-chloro-3-hydroxy-4-methoxybenzaldehyde 
• 67287-36-9 2-(2-chloro-3,4-dimethoxyphenyl)ethylamine 
• 7537-07-7 2-(2-chloro-3,4-dimethoxyphenyl)acetonitrile 
• 93983-13-2 2-chloro-3,4-dimethoxybenzyl alcohol 
• 74427-18-2 N-(2-chloro-3,4-dimethoxyphenylethyl)-4-methoxymandelamide 
• 72912-33-5 2-bromo-1-(tert-butoxy)-1-(4-methoxyphenyl)ethane 
• 75306-60-4 [2-tert-Butoxy-2-(4-methoxy-phenyl)-ethyl]-[2-(2-chloro-3,4-dimethoxy-phenyl)-ethyl]-amine 
• 100-06-1 1-(4-methoxyphenyl)ethanone 

Downstream Products

• 100166-68-5 2-[6-Chloro-7,8-dimethoxy-1-(4-methoxy-phenyl)-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl]-ethanol 
• 67227-56-9 fenoldopam 
• 110038-79-4 6-Chloro-2,3,4,5-tetrahydro-7-hydroxy-1-(4-hydroxyphenyl)-8-methoxy-1H-3-benzazepine hydrochloride 
• 110039-05-9 6-Chloro-2,3,4,5-tetrahydro-7-hydroxy-8-methoxy-1-(4-methoxyphenyl)-1H-3-benzazepine hydrochloride 
• 67287-54-1 Fenoldopam hydrobromide 
• 100166-63-0 [6-Chloro-7,8-dimethoxy-1-(4-methoxy-phenyl)-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl]-cyclopropyl-methanone 
• 77386-10-8 3-allyl-6-chloro-7,8-dimethoxy-1-(4-methoxyphenyl)2,3,4,5-tetrahydro-1H-3-benzazepine 
• 100166-60-7 6-Chloro-7,8-dimethoxy-1-(4-methoxy-phenyl)-1,2,4,5-tetrahydro-benzo[d]azepine-3-carbaldehyde 
• 87863-72-7 6-chloro-2,3,4,5-tetrahydro-1-(4-hydroxyphenyl)-3-methyl-1H-3-benzazepine-7,8-diol 
• 104113-95-3 6-Chloro-1-(4-hydroxy-phenyl)-3-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol; hydrobromide 
• 77386-12-0 SKF 85174 
• 101979-16-2 6-chloro-2,3,4,5-tetrahydro-1-(4-hydroxyphenyl)-3-(2-hydroxyethyl)-1H-3-bezazepine-7,8-diol 
• 81941-94-8 6-chloro-3-(cyclopropylmethyl)-2,3,4,5-tetrahydro-1-(4-hydroxyphenyl)-1H-3-benzazepine-7,8-diol 
• 81941-90-4 6-Chloro-3-cyclopropylmethyl-7,8-dimethoxy-1-(4-methoxy-phenyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine 

Relevant articles and documents

A hand natural Philippines Duopan splitting method

The invention discloses resolution of a D1 dopamine receptor agonist drug and in particular discloses a resolution method of fenoldopam. The resolution method of the D1 dopamine receptor agonist drug comprises the steps of protecting a phenolic hydroxyl group and an amino group in the structure of fenoldopam, then carrying out chemical resolution with a chiral acidic resolution agent to obtain a pure optical isomer, and finally removing a protecting group and salifying to obtain optically pure methanesulfonic acid fenoldopam.

Synthesis and renal vasodilator activity of some dopamine agonist 1-aryl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diols: Halogen and methyl analogues of fenoldopam

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Benz-tetrasubstituted 1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines

A group of 6,9-disubstituted-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines have dopaminergic activity. Examples of leading species of the invention are 6,9-dichloro-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine and 6,9-dichloro-7,8-dihydroxy-1-(p-hydroxy-phenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine in the form of an acid addition salt.