6732-01-0

Basic information

• Product Name: CHOLESTEROL HYDROGEN PHTHALATE
• Synonyms: PHTHALIC ACID MONOCHOLESTEROL ESTER;5-CHOLESTEN-3-BETA-OL HYDROGEN PHTHALATE;CHOLESTEROL HYDROGEN PHTHALATE;CHOLESTERYL HYDROGEN PHTHALATE;cholest-5-en-3beta-yl hydrogen phthalate;Phthalic acid 1-(3β-cholesteryl) ester;Phthalic acid hydrogen 1-(3β-cholesteryl) ester;Phthalic acid hydrogen 1-(3β-cholest
• CAS NO: 6732-01-0
• Molecular Formula: C₃₅H₅₀O₄
• Molecular Weight: 534.77
• EINECS: 229-783-9
• Product Categories: Cholesteryl Compounds (Liquid Crystals);Functional Materials;Liquid Crystals & Related Compounds
• Mol File: 6732-01-0.mol
• Article Data: 1

Chemical Properties

• Melting Point: 163 °C
• Boiling Point: 631.8°C at 760 mmHg
• Flash Point: 191.8°C
• Appearance: /
• Density: 1.11g/cm³
• Vapor Pressure: 7.89E-17mmHg at 25°C
• Refractive Index: 1.561
• PKA: 3.36±0.36(Predicted)
• CAS DataBase Reference: CHOLESTEROL HYDROGEN PHTHALATE(CAS DataBase Reference)
• NIST Chemistry Reference: CHOLESTEROL HYDROGEN PHTHALATE(6732-01-0)
• EPA Substance Registry System: CHOLESTEROL HYDROGEN PHTHALATE(6732-01-0)

Safety Data

• Hazardous Substances Data: 6732-01-0(Hazardous Substances Data)

Usage

General Description

Cholesterol hydrogen phthalate is a chemical compound that is a derivative of cholesterol, an essential component of cell membranes and a precursor for the synthesis of hormones and vitamin D. Cholesterol hydrogen phthalate is a phthalate ester, with a hydrogen atom replacing one of the alcohol groups of cholesterol and a phthalate group attached. It is used in various pharmaceutical and industrial applications as a solubility enhancer, a drug delivery vehicle, and a plasticizer. It is also under investigation for potential use as a photodynamic therapy agent for cancer treatment. Cholesterol hydrogen phthalate is of interest for its unique properties and potential applications in the medical and industrial fields.

InChI:InChI=1/C35H50O4/c1-22(2)9-8-10-23(3)29-15-16-30-28-14-13-24-21-25(17-19-34(24,4)31(28)18-20-35(29,30)5)39-33(38)27-12-7-6-11-26(27)32(36)37/h6-7,11-13,22-23,25,28-31H,8-10,14-21H2,1-5H3,(H,36,37)/t23-,25+,28+,29-,30+,31+,34+,35-/m1/s1

Upstream product

• 85-44-9 phthalic anhydride 
• 57-88-5 cholesterol 
• 57-88-5 cholesterol 

Relevant articles and documents

Connector type-controlled mesophase structures in poly(propyl ether imine) dendritic liquid crystals of identical dendrimer generations

Poly(propyl ether imine) (PETIM) dendrimers of one to three generations are used as dendritic cores to identify the influence of varying connector types that connect the dendritic core with peripheral mesogens on the emerging liquid crystalline (LC) properties. The LC properties vary in these dendritic liquid crystals, even when the dendrimer generations and thus the number of peripheral mesogenic moieties remain identical. PETIM dendrimer generations one to three, ester and amide connectors varying with succinates, phthalates, and succinamides, are studied herein. Cholesteryl moieties are installed at the peripheries through the above connectors to induce mesogenic properties. These modified dendritic liquid crystals reveal a layered mesophase structure in most ester and amide connector-derivatives, whereas a third-generation phthalate ester dendrimer favors a rectangular columnar mesophase structure. A transition from layered to a rectangular columnar structure results by a mere change in the connector varying between a succinate or succinamide or phthalate, within one particular dendrimer generation and without altering the underlying dendrimer core or the number of mesogenic moieties. The study demonstrates that in dendritic liquid crystals with essentially identical chemical constitutions, a change in the connector type connecting the mesogen with the dendrimer core is sufficient to change the mesophase structures.