674-53-3

Basic information

• Product Name: 4,4,4-TRIFLUOROBUT-2-EN-1-OL
• Synonyms: 4,4,4-TRIFLUORO-2-BUTEN-1-OL;4,4,4-TRIFLUOROBUT-2-EN-1-OL;4,4,4-Trifluorobut-2-en-1-ol 97%;4,4,4-Trifluorobut-2-en-1-ol97%;4,4,4-TRIFLUOROBUT-2-EN-1-OL, MIXTURE OF E/Z ISOMERS;4,4,4-Trifluorocrotyl alcohol 97%;4,4,4-Trifluorobut-2-en-1-ol, 4-Hydroxy-1,1,1-trifluorobut-2-ene;4,4,4-Trifluorocrotyl alcohol
• CAS NO: 674-53-3
• Molecular Formula: C₄H₅F₃O
• Molecular Weight: 126.08
• Mol File: 674-53-3.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 118-119°C
• Flash Point: 51 °C
• Appearance: /
• Density: 1.235 g/cm³
• Vapor Pressure: 26.1mmHg at 25°C
• Refractive Index: 1.361
• PKA: 13.15±0.10(Predicted)
• CAS DataBase Reference: 4,4,4-TRIFLUOROBUT-2-EN-1-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 4,4,4-TRIFLUOROBUT-2-EN-1-OL(674-53-3)
• EPA Substance Registry System: 4,4,4-TRIFLUOROBUT-2-EN-1-OL(674-53-3)

Safety Data

• Hazard Codes: Xi,F
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT, FLAMMABLE
• Hazardous Substances Data: 674-53-3(Hazardous Substances Data)

Usage

General Description

4,4,4-TRIFLUOROBUT-2-EN-1-OL is a chemical compound with the molecular formula C4H5F3O. It is a highly reactive and toxic compound that is primarily used as an intermediate in the production of other chemicals. 4,4,4-TRIFLUOROBUT-2-EN-1-OL is a colorless liquid with a sharp, pungent odor. It is flammable and can release toxic fumes when heated. It is important to handle this chemical with care and use appropriate safety measures when working with it.

InChI:InChI=1/C4H5F3O/c5-4(6,7)2-1-3-8/h1-2,8H,3H2/b2-1+

Upstream product

• 674-35-1 4,4,4-Trifluor-2-iod-buten-(2)-ol-(1) 
• 25597-16-4 ethyl 4,4,4-trifluorobut-2-enoate 
• 75-63-8 Bromotrifluoromethane 
• 107-19-7 propargyl alcohol 
• 2314-97-8 iodotrifluoromethane 
• 728040-39-9 4,4,4-trifluorobutenol acetate 

Downstream Products

• 1536-55-6 γ-Trifluormethylallyl-p-brombenzolsulfonat 
• 286836-16-6 1-(1-trifluoromethylprop-1-en-3-yloxy)-2-bromo-4-fluorobenzene 
• 871917-92-9 4,4,4-trifluoro-2-butenyl p-toluenesulfonate 
• 406-88-2 4,4,4-trifluorocrotonaldehyde 

Relevant articles and documents

Practical synthesis of 4,4,4-trifluorocrotonaldehyde: A versatile precursor for the enantioselective formation of trifluoromethylated stereogenic centers via organocatalytic 1,4-additions

The practical synthesis of 4,4,4-trifluorocrotonaldehyde (1) and its application to enantioselective 1,4-additions are described. The organocatalytic 1,4-addition of 1 with several nucleophiles such as heteroaromatics, alkylthiols and aldoximes afforded t

Ultrasound-Promoted Selective Perfluoroalkylation on the Desired Position of Organic Molecules

Perfluoroalkylzinc iodides or bromides wich were prepared from perfluoroalkyl iodides or bromides and zinc powder in N,N-dimethylformamide or tetrahydrofuran with ultrasonic irradiation were found to behave as potential perfluoroalkylating reagents for the preparation of a wide variety of perfluoroalkylated compounds.Especially, the ultrasound-promoted asymmetric induction with perfluoroalkyl group on the asymmetrical carbon was achieved by the reaction of perfluoroalkyl halides with optically active enamines in the presence of zinc powder and a catalytic amount of dichlorobis(?-cyclopentadienyl)titanium.

ULTRASOUND-PROMOTED HYDRPERFLUOROALKYLATION OF ALKYNES WITH PERFLUOROALKYLZINC IODIDE AND COPPER(I) IODIDE

The reaction of perfluoroalkyl iodides with terminal alkynes and ultrasonically dispersed zinc in the presence of copper(I) iodide proceeded smoothly to give the corresponding vinyl perfluoroalkylides in good yields.