67413-26-7

Basic information

• Product Name: (S)-2-Aziridinecarboxylic acid benzyl ester
• Synonyms: (S)-2-Aziridinecarboxylic acid benzyl ester
• CAS NO: 67413-26-7
• Molecular Formula: C₁₀H₁₁NO₂
• Molecular Weight: 177.2
• Mol File: 67413-26-7.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (S)-2-Aziridinecarboxylic acid benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-Aziridinecarboxylic acid benzyl ester(67413-26-7)
• EPA Substance Registry System: (S)-2-Aziridinecarboxylic acid benzyl ester(67413-26-7)

Safety Data

• Hazardous Substances Data: 67413-26-7(Hazardous Substances Data)

Usage

General Description

(S)-2-Aziridinecarboxylic acid benzyl ester, also known as benzyl (S)-2-aziridinecarboxylate, is a chemical compound with the molecular formula C11H13NO2. It is an ester derivative of (S)-2-aziridinecarboxylic acid, which is a key intermediate in the synthesis of various pharmaceuticals and agrochemicals. The compound is used as a reagent in organic synthesis and has applications in the production of diverse chemical compounds. It is important to handle this compound with care, as it can be hazardous if not used properly. Overall, (S)-2-Aziridinecarboxylic acid benzyl ester plays a crucial role in the preparation of important compounds in the field of pharmaceuticals and agrochemicals.

Upstream product

• 86852-11-1 diethoxyltriphenylphosphorane 
• 1738-72-3 L-serine benzyl ester 
• 67413-25-6 benzyl (-)-(2S)-1-trityl-aziridine-2-carboxylate 
• 67553-36-0 benzyl 3-hydroxy-2-(tritylamino)propanoate 
• 104597-98-0 (S)-2-methoxycarbonyl-1-benzyloxycarbonylaziridine 
• 100-51-6 benzyl alcohol 
• 153381-07-8 (S)-N-methoxycarbonyl aziridine-2-carboxylatemethyl ester 
• 100-39-0 benzyl bromide 

Downstream Products

• 86961-11-7 benzyl (S)-N-carbethoxyaziridinecarboxaldehyde 
• 84437-84-3 Z-Ala-Azy-OBzl 
• 131353-64-5 benzyl N-(N-(tert-butyloxycarbonyl)phenylalanyl)-L-aziridine-2-carboxylate 
• 83824-80-0 benzyl (2S)-1-benzyloxycarbonyl-aziridine-2-carboxylate 
• 16214-42-9 N-benzyloxycarbonyl-S-benzyl-L-cysteine benzyl ester 
• 126908-69-8 Z-Ala-Ser(Bz)-OBzl 
• 83824-83-3 (S)-2-Benzyloxycarbonylamino-3-isopropoxy-propionic acid benzyl ester 
• 20700-93-0 Z-Ser(O-t-Bu)-OBn 
• 83824-86-6 (S)-3-Benzyloxy-2-benzyloxycarbonylamino-propionic acid benzyl ester 
• 83824-85-5 (S)-2-Benzyloxycarbonylamino-3-cyclohexyloxy-propionic acid benzyl ester 
• 86961-12-8 (2R)-O-benzyl N-carbethoxy-S-(2-carbethoxy-n-propyl)-L-cysteine 
• 86961-13-9 (R)-2-Ethoxycarbonylamino-3-((S)-2-methoxycarbonyl-propylsulfanyl)-propionic acid benzyl ester 

Relevant articles and documents

COVALENT RAS INHIBITORS AND USES THEREOF

The disclosure features compounds, or pharmaceutically acceptable salts thereof, alone and in combination with other therapeutic agents, pharmaceutical compositions, and protein conjugates thereof, capable of modulating biological processes including Ras, and their uses in the treatment of cancers.

Selective cleavage of carbamate protecting groups from aziridines with otera's catalyst

Otera's distannoxane catalyst was found to promote the cleavage of carbamate groups from N-protected aziridines. This method enables the chemoselective cleavage of an aziridinyl N-carbobenzyloxy (Cbz) group in the presence of other N-Cbz groups. The selec

An expeditious in situ preparation of benzyl (S)-2-aziridinecarboxylate

The use of diethoxytriphenylphosphorane in the preparation of benzyl (S)-2-aziridinecarboxylate is illustrated.The latter compound has been coupled with Z-Ala-OH and the aziridine dipeptide thus obtained ring-opened via C-3-N-1 cleavage with benzyl alcoho