67469-81-2 Usage
Description
1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE DIHYDROCHLORIDE, also known as a hydrochloride salt derived from 1-[2-(benzhydryloxy)ethyl]-4-(3-phenylpropyl)piperazine, is a potent and selective inhibitor of dopamine uptake. It is characterized by its high affinity for dopamine transporters, making it a significant compound in the field of neuroscience and pharmacology.
Uses
Used in Pharmaceutical Industry:
1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE DIHYDROCHLORIDE is used as a potent and selective inhibitor of dopamine uptake for the development of medications targeting neurological disorders and conditions related to dopamine dysregulation. Its high affinity for dopamine transporters makes it a valuable tool in the research and treatment of such disorders.
Used in Research Applications:
In the field of neuroscience research, 1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE DIHYDROCHLORIDE serves as a valuable research tool for studying the role of dopamine in various brain functions and disorders. Its potent and selective inhibition of dopamine uptake allows researchers to investigate the underlying mechanisms and potential therapeutic targets for conditions such as Parkinson's disease, schizophrenia, and addiction.
Used in Drug Development:
1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE DIHYDROCHLORIDE is utilized in the development of new drugs aimed at modulating dopamine levels in the brain. Its potent and selective action on dopamine transporters makes it a promising candidate for the creation of novel therapeutic agents that can effectively treat a range of neurological and psychiatric conditions.
Biochem/physiol Actions
GBR 12935 inhibits the dopamine and norepinephrine transporters with Kis of 21.5 nM and 225 nM, respectively. It does not inhibit the serotonin transporter (Ki = 6.5 mM). GBR 12935 binds to a nondopaminergic piperazine site in blood platelets and brain that has been identified as cytochrome P450.
Check Digit Verification of cas no
The CAS Registry Mumber 67469-81-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,7,4,6 and 9 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 67469-81:
(7*6)+(6*7)+(5*4)+(4*6)+(3*9)+(2*8)+(1*1)=172
172 % 10 = 2
So 67469-81-2 is a valid CAS Registry Number.
InChI:InChI=1/C28H34N2O.ClH/c1-4-11-25(12-5-1)13-10-18-29-19-21-30(22-20-29)23-24-31-28(26-14-6-2-7-15-26)27-16-8-3-9-17-27;/h1-9,11-12,14-17,28H,10,13,18-24H2;1H
67469-81-2Relevant articles and documents
N-Benzhydryloxyethyl-N-phenylpropyl-piperazines
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, (2008/06/13)
Piperazine derivatives of the general formula STR1 wherein R1 -R9 are the same or different and each represents a hydrogen or halogen atom or a lower alkyl or lower alkoxy group, n is 2 or 3 and X represents a group (CH2)m (in which m is 1, 2, 3 or 4) or a group --CH2 --CH=CH--, having methylene linked to the piperazine group, and acid addition and quaternary ammonium salts thereof, are described. The compounds exhibit a strong specific dopaminergic activity. Also described are methods for their preparation and use as therapeutic agents in the form of therapeutic compositions.
