675596-31-3

Basic information

• Product Name: 2'-TRIFLUOROMETHYL-BIPHENYL-3-CARBALDEHYDE
• Synonyms: AKOS BAR-2337;3-(2-(Trifluoromethyl)phenyl)benzaldehyde;2'-Trifluoromethyl-biphenyl-3-carbaldehyde;[1,1'-Biphenyl]-3-carboxaldehyde, 2'-(trifluoroMethyl)-;2'-(TrifluoroMethyl)-[1,1'-biphenyl]-3-carbaldehyde;2'-TRIFLUOROMETHYL-BIPHENYL-3-CARBALDEHYDE
• CAS NO: 675596-31-3
• Molecular Formula: C₁₄H₉F₃O
• Molecular Weight: 250.22
• Product Categories: Biphenyl & Diphenyl ether
• Mol File: 675596-31-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 343.1±42.0 °C(Predicted)
• Appearance: /
• Density: 1.251±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2'-TRIFLUOROMETHYL-BIPHENYL-3-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-TRIFLUOROMETHYL-BIPHENYL-3-CARBALDEHYDE(675596-31-3)
• EPA Substance Registry System: 2'-TRIFLUOROMETHYL-BIPHENYL-3-CARBALDEHYDE(675596-31-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26
• Hazardous Substances Data: 675596-31-3(Hazardous Substances Data)

Usage

General Description

2'-Trifluoromethyl-biphenyl-3-carbaldehyde is a chemical compound with a molecular formula C14H11F3O. It is a yellow-colored liquid with a molecular weight of 250.23 g/mol. 2'-TRIFLUOROMETHYL-BIPHENYL-3-CARBALDEHYDE is used as a building block in organic synthesis and pharmaceutical research. Its trifluoromethyl group imparts unique chemical properties, making it valuable for the development of new drugs and agrochemicals. Additionally, this compound is used as a precursor in the synthesis of various biologically active molecules, making it an important intermediate in the pharmaceutical industry. Its properties and versatility make it a valuable tool in the field of chemical research and drug discovery.

Upstream product

• 3132-99-8 m-bromobenzoic aldehyde 
• 1423-27-4 2-(trifluoromethyl)phenylboronic acid 
• 392-83-6 o-trifluoromethylphenyl bromide 
• 87199-16-4 3-Formylphenylboronic acid 

Relevant articles and documents

Design, synthesis and biological evaluation of novel FFA1/GPR40 agonists: New breakthrough in an old scaffold

Based on an old phenoxyacetic acid scaffold, CPU014 (compound 14) has been identified as a superior agonist by comprehensive exploration of structure-activity relationship. In vitro toxicity study suggested that CPU014 has lower risk of hepatotoxicity than TAK-875. During acute toxicity study (5–500 mg/kg), a favorable therapeutic window of CPU014 was observed by evaluation of plasma profiles and liver slices. Moreover, CPU014 promotes insulin secretion in a glucose-dependent manner, while no GLP-1 secretion has been enhanced. Other than good pharmacokinetic properties, CPU014 significantly improved glucose tolerance both in normal and diabetic models without the risk of hypoglycemia. These subversive findings provided a safer candidate CPU014, which is currently in preclinical study to assess its potential for the treatment of diabetes.

Discovery and structure-activity relationships of pyrrolone antimalarials

In the pursuit of new antimalarial leads, a phenotypic screening of various commercially sourced compound libraries was undertaken by the World Health Organisation Programme for Research and Training in Tropical Diseases (WHO-TDR). We report here the detailed characterization of one of the hits from this process, TDR32750 (8a), which showed potent activity against Plasmodium falciparum K1 (EC50 ～ 9 nM), good selectivity (>2000-fold) compared to a mammalian cell line (L6), and significant activity against a rodent model of malaria when administered intraperitoneally. Structure-activity relationship studies have indicated ways in which the molecule could be optimized. This compound represents an exciting start point for a drug discovery program for the development of a novel antimalarial.