67567-26-4 Usage
Description
4-Bromo-2,6-difluoroaniline is an organic compound with the chemical formula C6H3BrF2N. It is characterized by its off-white crystalline appearance and is known for its reactivity in various chemical synthesis processes.
Uses
1. Used in Chemical Synthesis:
4-Bromo-2,6-difluoroaniline is used as a key intermediate in the synthesis of various compounds, including:
a. Ammonium 5-bromo-7-fluorobenzo-2-oxa-1,3-diazole-4-sulphonate, which serves as a fluorogenic derivatizating reagent for the determination of aminothiols by high-performance liquid chromatography (HPLC).
b. Fluorogenic derivatizating reagents for the determination of aminothiols by HPLC.
c. Specific olefin tolanes, which are valuable in the field of organic chemistry.
d. 1-(4-amino-3,5-difluoro)-2-(4-butyloxyphenyl)ethyne, a compound with potential applications in material science and pharmaceuticals.
e. 4′′-n-butyloxy-3,5-difluoroterphenyl-4-amine, which may have applications in the development of advanced materials and pharmaceuticals.
f. 4-(3-methylbut-1-yn-3-ol)-2,6-difluoroaniline, a compound that could be used in the synthesis of various organic molecules.
2. Used in Pharmaceutical Industry:
4-Bromo-2,6-difluoroaniline is used as a starting material in the preparation of potent VEGF (Vascular Endothelial Growth Factor) receptor tyrosine kinase inhibitors. These inhibitors play a crucial role in the development of anti-cancer drugs, as they help in blocking the growth of new blood vessels that supply nutrients to the tumor, thereby inhibiting tumor growth and progression.
Check Digit Verification of cas no
The CAS Registry Mumber 67567-26-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,7,5,6 and 7 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 67567-26:
(7*6)+(6*7)+(5*5)+(4*6)+(3*7)+(2*2)+(1*6)=164
164 % 10 = 4
So 67567-26-4 is a valid CAS Registry Number.
InChI:InChI=1/C6H4BrF2N/c7-3-1-4(8)6(10)5(9)2-3/h1-2H,10H2
67567-26-4Relevant articles and documents
Sensitized Two-NIR-Photon Z→E Isomerization of a Visible-Light-Addressable Bistable Azobenzene Derivative
Moreno, Javier,Gerecke, Mario,Grubert, Lutz,Kovalenko, Sergey A.,Hecht, Stefan
, p. 1544 - 1547 (2016)
Two-NIR-photon-triggered Z→E isomerization of an azobenzene was accomplished by covalently linking a two-photon-harvesting triarylamine antenna to a thermally stable ortho-fluorinated azobenzene derivative. The obtained photoswitch is fully addressable wi
Chemical tuning of photoswitchable azobenzenes: A photopharmacological case study using nicotinic transmission
Sansalone, Lorenzo,Zhao, Jun,Richers, Matthew T.,Ellis-Davies, Graham C.R.
supporting information, p. 2812 - 2821 (2019/12/11)
We have developed photochromic probes for the nicotinic acetylcholine receptor that exploit the unique chemical properties of the tetrafluoroazobenzene (4FAB) scaffold. Ultraviolet light switching and rapid thermal relaxation of the metastable cis configu
Modulating Guest Uptake in Core–Shell MOFs with Visible Light
Mutruc, Dragos,Goulet-Hanssens, Alexis,Fairman, Sam,Wahl, Sebastian,Zimathies, Annett,Knie, Christopher,Hecht, Stefan
supporting information, p. 12862 - 12867 (2019/08/08)
A two-component core–shell UiO-68 type metal–organic framework (MOF) with a nonfunctionalized interior for efficient guest uptake and storage and a thin light-responsive outer shell was prepared by initial solvothermal MOF synthesis followed by solvent-as
