6758-34-5 Usage
General Description
2-(Hydroxymethyl)-5-trifluoromethyl-1H-benzimidazole is a chemical compound that belongs to the benzimidazole class. It contains a hydroxyl group, a methyl group, and a trifluoromethyl group attached to a benzimidazole ring. 2-(HYDROXYMETHYL)-5-TRIFLUOROMETHYL-1H-BENZOIMIDAZOLE has potential pharmaceutical applications, with studies showing that it exhibits antioxidant, antimicrobial, and antifungal properties. It is also being investigated for its potential use in the treatment of neurodegenerative diseases due to its ability to modulate enzyme activities and protein production. However, further research is needed to fully understand its pharmacological potential and any potential side effects or toxicities.
Check Digit Verification of cas no
The CAS Registry Mumber 6758-34-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,7,5 and 8 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 6758-34:
(6*6)+(5*7)+(4*5)+(3*8)+(2*3)+(1*4)=125
125 % 10 = 5
So 6758-34-5 is a valid CAS Registry Number.
InChI:InChI=1/C9H7F3N2O/c10-9(11,12)5-1-2-6-7(3-5)14-8(4-15)13-6/h1-3,15H,4H2,(H,13,14)
6758-34-5Relevant articles and documents
Sustainable Synthesis of 2-Hydroxymethylbenzimidazoles using D-Fructose as a C2 Synthon
Raja, Dineshkumar,Philips, Abigail,Sundaramurthy, Devikala,Chandru Senadi, Gopal
supporting information, p. 3754 - 3759 (2021/10/14)
D-fructose, a biomass-derived carbohydrate has been identified as an environmentally benign C2 synthon in the preparation of synthetically useful 2-hydroxymethylbenzimidazole derivatives by coupling with 1,2-phenylenediamines. Proof of concept was established by synthesizing 23 examples using BF3.OEt2 (20 mol%), TBHP (5.5 M, decane) (1.0 equiv.) in CH3CN at 90 °C for 1 h. The pivotal features of this method include metal-free conditions, short time, good functional group tolerance, gram scale feasibility and the synthesis of benzimidazole fused 1,4-oxazine. Control studies with conventional C2 synthons did not produce the desired product, thus suggesting a new reaction pathway from D-fructose.