676154-53-3

Basic information

• Product Name: 4-benzyl-5-(quinolin-2-yl)-4H-1,2,4-triazol-3-thiol
• Synonyms: 4-benzyl-5-(quinolin-2-yl)-4H-1,2,4-triazol-3-thiol
• CAS NO: 676154-53-3
• Molecular Weight: 318.402
• Mol File: 676154-53-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-benzyl-5-(quinolin-2-yl)-4H-1,2,4-triazol-3-thiol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-benzyl-5-(quinolin-2-yl)-4H-1,2,4-triazol-3-thiol(676154-53-3)
• EPA Substance Registry System: 4-benzyl-5-(quinolin-2-yl)-4H-1,2,4-triazol-3-thiol(676154-53-3)

Safety Data

• Hazardous Substances Data: 676154-53-3(Hazardous Substances Data)

Upstream product

• 903178-41-6 N-benzyl-2-(quinolin-2-ylcarbonyl)hydrazincarbothioamide 
• 93-10-7 quinoline-2-carboxylic acid 
• 4491-33-2 ethyl quinoline-2-carboxylate 
• 5382-44-5 quinoline-2-carboxylic acid hydrazide 
• 622-78-6 Benzyl isothiocyanate 

Downstream Products

• 1383551-00-5 4-benzyl-2-(morpholin-4-ylmethyl)-5-(quinolin-2-yl)-2,4-dihydro-3H-1,2,4-triazol-3-thione 
• 1383551-01-6 4-benzyl-2-[(4-methylpiperazin-1-yl)methyl]-5-(quinolin-2-yl)-2,4-dihydro-3H-1,2,4-triazol-3-thione 

Relevant articles and documents

Preparation and antimicrobial activity evaluation of some quinoline derivatives containing an azole nucleus

Quinoline-2-carbohydrazide (2) obtained from quinaldic acid (1) was converted to the corresponding carbothioamide 3 and carboxamide 6 by treatment with benzyliso(thio)cyanate. The basic treatment of 3 and 6 yielded the corresponding 1,2,4-triazole derivatives 4 and 7. The synthesis of 5-(quinolin-2-yl)-1,3,4- oxadiazol-2-thiol (9) was performed from the reaction of 1 with CS2 in basic media. The Mannich reaction of compounds 4, 7, and 9 resulted in the formation of aminoalkylated derivatives 5a-c, 8, and 10a,b. The condensation of 1 with thiosemicarbazide, carbohydrazide, or thiocarbohydrazide gave the corresponding 1,2,4-triazole derivatives (11-13). The treatment of 4-amino-5-(quinolin-2-yl)-4H -1,2,4-triazole-3-thiol (13) with 4-chlorophenacyl bromide caused the formation of fused triazolothiadiazine 14. The condensation of 13 with 4-methoxybenzaldehyde generated the corresponding Schiff base 15. The newly synthesized compounds were characterized by elemental analyses, IR, 1H-NMR, 13C-NMR, and mass spectra. The antimicrobial activity study revealed that some of the newly synthesized compounds showed good to moderate activity against a variety of microorganisms.