67617-63-4Relevant articles and documents
Chiral ferrocene-imidazole diphosphine ligand as well as synthesis method and application thereof
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Paragraph 0047-0051; 0060-0063, (2021/05/22)
The invention relates to a chiral ferrocene-imidazole diphosphine ligand as well as a preparation method and application thereof. The synthesis method comprises the following steps: dissolving ferrocenyl chiral alcohol and N, N '-carbonyldiimidazole, whic
A Novel esterase from Pseudochrobactrum asaccharolyticum WZZ003: Enzymatic properties toward model substrate and catalytic performance in chiral fungicide intermediate synthesis
Cheng, Feng,Cheng, Feifei,Zheng, Jianyong,Wu, Guanzhong,Zhang, Yinjun,Wang, Zhao
, p. 92 - 98 (2018/03/29)
Only a few esterases have been used for the synthesis of optically pure fungicide. For example, (R)-metalaxyl synthesized using esterase-involved bioreaction displays fungicide activity, whereas (S)-enantiomer is redundant. However, the biosynthesis of (R
Enantiomerization and enantioselective bioaccumulation of metalaxyl in tenebrio molitor larvae
Gao, Yongxin,Wang, Huili,Qin, Fang,Xu, Peng,Lv, Xiaotian,Li, Jianzhong,Guo, Baoyuan
, p. 88 - 94 (2014/03/21)
The enantiomerization and enantioselective bioaccumulation of metalaxyl by a single dose of exposure to Tenebrio molitor larvae under laboratory condition were studied by high-performance liquid chromatography tandem mass spectroscopy (HPLC-MS/MS) based on a ChiralcelOD-3R [cellulosetris-tris-(3, 5-dichlorophenyl-carbamate)] column. Exposure of enantiopure R-metalaxyl and S-metalaxyl in Tenebrio molitor larvae exhibited significant enantiomerization, with formation of the R enantiomers from the S enantiomers, and vice versa, which might be attributed to the chiral pesticide catalyzed by a certain enzyme in Tenebrio molitor larvae. Enantiomerization was not observed in wheat bran during the period of 21 d. In addition, bioaccumulation of rac-metalaxyl in Tenebrio molitor larvae was enantioselective with a preferential accumulation of S-metalaxyl. These results showed that enantioselectivity was caused not only by actual degradation and metabolism but also by enantiomerization, which was an important process in the environmental fate and behavior of metalaxyl enantiomers.